Idioma:

Chemical-functional diversity in cell-penetrating peptides

Stalmans, Sofie ; Wynendaele, Evelien ; Bracke, Nathalie ; Gevaert, Bert ; D'Hondt, Matthias ; Peremans, Kathelijne ; Burvenich, Christian ; De Spiegeleer, Bart Taylor, Paul

PloS one, 2013-08, Vol.8 (8), p.e71752 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Chemical-functional diversity in cell-penetrating peptides
Autor: Stalmans, Sofie ; Wynendaele, Evelien ; Bracke, Nathalie ; Gevaert, Bert ; D'Hondt, Matthias ; Peremans, Kathelijne ; Burvenich, Christian ; De Spiegeleer, Bart
Taylor, Paul
Assuntos: Amino acids ; Analysis ; Animals ; Atomic structure ; Biological Transport ; Biology ; Biometrics ; Cancer ; Cell Line ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Cell Membrane Permeability ; Cell-Penetrating Peptides - chemistry ; Cell-Penetrating Peptides - pharmacology ; Cellular structure ; Chemistry ; Chemotherapy ; Deoxyribonucleic acid ; DNA ; Escherichia coli - drug effects ; Escherichia coli - metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Medical imaging ; Medicine ; Neural networks ; Peptides ; Pharmaceutical sciences ; Physiology ; Plasmid DNA ; Plasmids ; Principal Component Analysis ; Principal components analysis ; Properties (attributes) ; Property values ; Protein Conformation ; Proteins ; Quality ; Quantitative Structure-Activity Relationship ; Registration ; Ribonucleic acid ; RNA ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - metabolism ; Static Electricity ; Veterinary medicine
É parte de: PloS one, 2013-08, Vol.8 (8), p.e71752
Notas: Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: SS BDS. Performed the experiments: SS NB EW BG MD. Analyzed the data: SS BDS. Contributed reagents/materials/analysis tools: KP CB. Wrote the paper: SS BDS.
Descrição: Cell-penetrating peptides (CPPs) are a promising tool to overcome cell membrane barriers. They have already been successfully applied as carriers for several problematic cargoes, like e.g. plasmid DNA and (si)RNA, opening doors for new therapeutics. Although several hundreds of CPPs are already described in the literature, only a few commercial applications of CPPs are currently available. Cellular uptake studies of these peptides suffer from inconsistencies in used techniques and other experimental conditions, leading to uncertainties about their uptake mechanisms and structural properties. To clarify the structural characteristics influencing the cell-penetrating properties of peptides, the chemical-functional space of peptides, already investigated for cellular uptake, was explored. For 186 peptides, a new cell-penetrating (CP)-response was proposed, based upon the scattered quantitative results for cellular influx available in the literature. Principal component analysis (PCA) and a quantitative structure-property relationship study (QSPR), using chemo-molecular descriptors and our newly defined CP-response, learned that besides typical well-known properties of CPPs, i.e. positive charge and amphipathicity, the shape, structure complexity and the 3D-pattern of constituting atoms influence the cellular uptake capacity of peptides.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Chemical-functional diversity in cell-penetrating peptides

Stalmans, Sofie ; Wynendaele, Evelien ; Bracke, Nathalie ; Gevaert, Bert ; D'Hondt, Matthias ; Peremans, Kathelijne ; Burvenich, Christian ; De Spiegeleer, Bart Taylor, Paul

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.