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Research progress of opioid growth factor in immune-related diseases and cancer diseases

Huang, Hai ; Liu, Bing ; Qu, Na ; Zhang, Shuling ; Bai, Xueli ; Handley, Mike ; Shan, Fengping

International immunopharmacology, 2021-10, Vol.99, p.107713-107713, Article 107713 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Research progress of opioid growth factor in immune-related diseases and cancer diseases
Autor: Huang, Hai ; Liu, Bing ; Qu, Na ; Zhang, Shuling ; Bai, Xueli ; Handley, Mike ; Shan, Fengping
Assuntos: Animal diseases ; Animals ; Autoimmune diseases ; Cancer ; Cancer therapy ; Cell cycle ; Cell proliferation ; Deoxyribonucleic acid ; Diabetes mellitus ; DNA ; DNA biosynthesis ; Enkephalin, Methionine - metabolism ; Enkephalins ; Growth factors ; Humans ; Immune response ; Immune system ; Immune System Diseases - drug therapy ; Immune System Diseases - metabolism ; Immunomodulation ; Immunomodulators ; Immunoregulation ; Immunosuppressive agents ; Inflammatory bowel diseases ; Methionine ; Methionine enkephalin ; Molecular modelling ; Multiple sclerosis ; Narcotic Antagonists - therapeutic use ; Narcotics ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Opioid growth factor ; Opioids ; S phase ; Signs and symptoms ; Tumors
É parte de: International immunopharmacology, 2021-10, Vol.99, p.107713-107713, Article 107713
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: •OGF plays a role in the treatment of immune-related diseases and cancer.•OGF can extensively stimulate immune cells though opioid receptor mediation.•OGF has great potential as an alternative method to treat human cancer. Methionine enkephalin (MENK) has an important role in both neuroendocrine and immune systems. MENK was known as an opioid growth factor (OGF) for its growth regulatory characteristics. OGF interacts with the OGF receptor (OGFr) to inhibit DNA synthesis by upregulating p16 and/or p21, which delays the cell cycle transition from G0/G1 to S phase, and inhibits cell proliferation. In addition, OGF combines with OGFr in immune cells to exert its immunomodulatory activity and regulate immune function. OGF has been studied as an immunomodulator in a variety of autoimmune diseases, including multiple sclerosis, inflammatory bowel disease, diabetes and viral infections, and has been proven to relieve symptoms of certain diseases in animal and in vitro experiments. Also, OGF and OGFr have various anti-tumor molecular mechanisms. OGF can be used as the primary therapy alone or combined with other drugs to treat tumors. This article summarizes the research progress of OGF in immune-related diseases and cancer diseases.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Research progress of opioid growth factor in immune-related diseases and cancer diseases

Huang, Hai ; Liu, Bing ; Qu, Na ; Zhang, Shuling ; Bai, Xueli ; Handley, Mike ; Shan, Fengping

Netherlands: Elsevier B.V

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