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The role of the P2X₇ receptor in infectious diseases

Miller, Catherine M ; Boulter, Nicola R ; Fuller, Stephen J ; Zakrzewski, Alana M ; Lees, Michael P ; Saunders, Bernadette M ; Wiley, James S ; Smith, Nicholas C Manchester, Marianne

PLoS pathogens, 2011-11, Vol.7 (11), p.e1002212-e1002212 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
The role of the P2X₇ receptor in infectious diseases
Autor: Miller, Catherine M ; Boulter, Nicola R ; Fuller, Stephen J ; Zakrzewski, Alana M ; Lees, Michael P ; Saunders, Bernadette M ; Wiley, James S ; Smith, Nicholas C
Manchester, Marianne
Assuntos: Amino acids ; Animals ; Apoptosis ; Bacteria ; Bacteria - immunology ; Bacterial Infections - immunology ; Bacterial Infections - metabolism ; Biology ; Cytokines ; Disease Susceptibility ; Humans ; Inflammasomes - metabolism ; Interleukin-18 - biosynthesis ; Interleukin-1beta - biosynthesis ; Ion Channels - metabolism ; Kinases ; Macrophages - metabolism ; Mitogen-Activated Protein Kinases - genetics ; Mitogen-Activated Protein Kinases - metabolism ; Nitric oxide ; Parasites ; Parasites - immunology ; Parasitic Diseases - immunology ; Parasitic Diseases - metabolism ; Phospholipase D - biosynthesis ; Proteins ; Reactive Oxygen Species - metabolism ; Receptors, Purinergic P2X7 - genetics ; Receptors, Purinergic P2X7 - metabolism ; Review ; Rodents ; Signal Transduction ; Studies
É parte de: PLoS pathogens, 2011-11, Vol.7 (11), p.e1002212-e1002212
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X₇ receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1β and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion. The P2X₇ receptor can initiate host mechanisms to remove pathogens, most particularly those that parasitise macrophages. At the same time, the P2X₇ receptor may be subverted by pathogens to modulate host responses. Moreover, recent genetic studies have demonstrated significant associations between susceptibility or resistance to parasites and bacteria, and loss-of-function or gain-of-function polymorphisms in the P2X₇ receptor, underscoring its importance in infectious disease.
Editor: United States: Public Library of Science
Idioma: Inglês

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The role of the P2X₇ receptor in infectious diseases

Miller, Catherine M ; Boulter, Nicola R ; Fuller, Stephen J ; Zakrzewski, Alana M ; Lees, Michael P ; Saunders, Bernadette M ; Wiley, James S ; Smith, Nicholas C Manchester, Marianne

United States: Public Library of Science

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