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The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation

Mascarell, L ; Airouche, S ; Berjont, N ; Gary, C ; Gueguen, C ; Fourcade, G ; Bellier, B ; Togbe, D ; Ryffel, B ; Klatzmann, D ; Baron-Bodo, V ; Moingeon, P

Mucosal immunology, 2017-05, Vol.10 (3), p.695-704 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation
Autor: Mascarell, L ; Airouche, S ; Berjont, N ; Gary, C ; Gueguen, C ; Fourcade, G ; Bellier, B ; Togbe, D ; Ryffel, B ; Klatzmann, D ; Baron-Bodo, V ; Moingeon, P
Assuntos: Allergens - immunology ; Animals ; Betula ; Cells, Cultured ; Complement C1q - administration & dosage ; Complement C1q - metabolism ; Dendritic Cells - immunology ; Eosinophils - immunology ; Female ; Humans ; Hypersensitivity - immunology ; Immunology ; Interleukin-10 - metabolism ; Life Sciences ; Lung - immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Ovalbumin - immunology ; Plant Extracts ; Pollen - immunology ; T-Lymphocytes, Regulatory - immunology ; Th2 Cells - immunology
É parte de: Mucosal immunology, 2017-05, Vol.10 (3), p.695-704
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SourceType-Scholarly Journals-1
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Descrição: The complement subunit C1q was recently identified as a marker for monocyte-derived regulatory dendritic cells supporting the differentiation of interleukin (IL)-10-secreting CD4 T cells with a suppressive activity. Furthermore, C1q expression is upregulated in peripheral blood mononuclear cells of allergic patients in the course of successful allergen immunotherapy. Herein, we investigated a potential direct role of C1q in downregulating allergic inflammation. In mice with ovalbumin (OVA) or birch pollen (BP)-induced allergic asthma, C1q is as efficacious as dexamethasone to reduce both airway hyperresponsiveness (AHR), eosinophil, and ILC2 infiltrates in bronchoalveolar lavages, as well as allergen-specific T helper 2 cells in the lungs. Administration of C1q does not expand IL-10 /Foxp3 regulatory T cells in the lungs, spleen, or in the blood. Depletion of plasmacytoid dendritic cells (pDCs) abrogates the capacity of C1q to reduce AHR and eosinophilic infiltrates in OVA-sensitized mice. Also C1q treatment inhibits the activation of human and mouse pDCs by CpGs, thereby demonstrating a critical role for pDCs in the anti-inflammatory activity of C1q. We conclude that regulatory dendritic cells can mediate a potent direct anti-inflammatory activity via the expression and/or secretion of molecules such as C1q, independently of their capacity to expand the pool of regulatory T cells.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation

Mascarell, L ; Airouche, S ; Berjont, N ; Gary, C ; Gueguen, C ; Fourcade, G ; Bellier, B ; Togbe, D ; Ryffel, B ; Klatzmann, D ; Baron-Bodo, V ; Moingeon, P

United States: Nature Publishing Group

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