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CPEB2, A Novel Putative Translational Regulator in Mouse Haploid Germ Cells

KURIHARA, Yasuyuki ; TOKURIKI, Motoyuki ; MYOJIN, Reiko ; HORI, Tamaki ; KUROIWA, Asato ; MATSUDA, Yoichi ; SAKURAI, Takayuki ; KIMURA, Minoru ; HECHT, Norman B ; UESUGI, Seiichi

Biology of reproduction, 2003-07, Vol.69 (1), p.261-268 [Periódico revisado por pares]

Madison, WI: Society for the Study of Reproduction

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Título:
CPEB2, A Novel Putative Translational Regulator in Mouse Haploid Germ Cells
Autor: KURIHARA, Yasuyuki ; TOKURIKI, Motoyuki ; MYOJIN, Reiko ; HORI, Tamaki ; KUROIWA, Asato ; MATSUDA, Yoichi ; SAKURAI, Takayuki ; KIMURA, Minoru ; HECHT, Norman B ; UESUGI, Seiichi
Assuntos: Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Chromosome Mapping ; Cloning, Molecular ; Cytoplasm - metabolism ; DNA, Complementary - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Haploidy ; HeLa Cells ; Hormone metabolism and regulation ; Humans ; Male ; Mammalian male genital system ; Mice ; Molecular Sequence Data ; Phylogeny ; Poly U - metabolism ; Protein Biosynthesis ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Spermatids - metabolism ; Spermatogenesis ; Tissue Distribution ; Transfection ; Vertebrates: reproduction
É parte de: Biology of reproduction, 2003-07, Vol.69 (1), p.261-268
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SourceType-Scholarly Journals-1
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Descrição: Translational control of specific mRNAs by cytoplasmic polyadenylation has fundamental roles in gametogenesis. The cytoplasmic polyadenylation element binding (CPEB) protein regulates cytoplasmic polyadenylation of mRNAs as a trans factor in oogenesis and spermatogenesis. The CPEB protein contains two RNA recognition motifs and a Zn-finger structure. Proteins (KIAA0940 and KIAA1673) with similar structures are predicted from the genome database, but nothing is known about their expression and function. Here, we report another novel member of the CPEB protein family, CPEB2. Comparison of the amino acid sequences of CPEB family members suggests that the family can be divided structurally and, perhaps, functionally into two groups: the CPEB group, and the CPEB2-KIAA0940-KIAA1673 group. The CPEB2 maps to mouse chromosome distal 5B and is abundantly expressed in testis. However, it was detected by reverse transcription-polymerase chain reaction in all tissues that we examined. It preferentially binds to poly(U) and localizes to the cytoplasm in transfected HeLa cells. The CPEB2 is expressed postmeiotically in mouse spermatogenesis, suggesting a possible role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids.
Editor: Madison, WI: Society for the Study of Reproduction
Idioma: Inglês

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CPEB2, A Novel Putative Translational Regulator in Mouse Haploid Germ Cells

KURIHARA, Yasuyuki ; TOKURIKI, Motoyuki ; MYOJIN, Reiko ; HORI, Tamaki ; KUROIWA, Asato ; MATSUDA, Yoichi ; SAKURAI, Takayuki ; KIMURA, Minoru ; HECHT, Norman B ; UESUGI, Seiichi

Madison, WI: Society for the Study of Reproduction

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