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Dynamic carriers for therapeutic RNA delivery

Berger, Simone ; Lächelt, Ulrich ; Wagner, Ernst

Proceedings of the National Academy of Sciences - PNAS, 2024-03, Vol.121 (11), p.e2307799120-e2307799120 [Periódico revisado por pares]

United States: National Academy of Sciences

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  • Título:
    Dynamic carriers for therapeutic RNA delivery
  • Autor: Berger, Simone ; Lächelt, Ulrich ; Wagner, Ernst
  • Assuntos: Biological Sciences ; Cell Membrane ; Cell membranes ; Cues ; Ion concentration ; Lipids ; Macromolecules ; Micelles ; Microenvironments ; Nanoparticles ; Physical Sciences ; Physicochemical properties ; Polycations ; Polyelectrolytes ; Polymers ; Redox potential ; Ribonucleic acid ; RNA
  • É parte de: Proceedings of the National Academy of Sciences - PNAS, 2024-03, Vol.121 (11), p.e2307799120-e2307799120
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Edited by Sangeeta Bhatia, Massachusetts Institute of Technology, Cambridge, MA; received June 8, 2023; accepted August 22, 2023
  • Descrição: Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA during delivery to the target tissue and across cellular membrane barriers and then releasing the cargo in bioactive form. The chemical space of carriers ranges from small cationic lipids applied in lipoplexes and lipid nanoparticles, over medium-sized sequence-defined xenopeptides, to macromolecular polycations applied in polyplexes and polymer micelles. This perspective highlights the discovery of distinct virus-inspired dynamic processes that capitalize on mutual nanoparticle-host interactions to achieve potent RNA delivery. From the host side, subtle alterations of pH, ion concentration, redox potential, presence of specific proteins, receptors, or enzymes are cues, which must be recognized by the RNA nanocarrier via dynamic chemical designs including cleavable bonds, alterable physicochemical properties, and supramolecular assembly-disassembly processes to respond to changing biological microenvironment during delivery.
  • Editor: United States: National Academy of Sciences
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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