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Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

Marchitto, Mark C. ; Dillen, Carly A. ; Liu, Haiyun ; Miller, Robert J. ; Archer, Nathan K. ; Ortines, Roger V. ; Alphonse, Martin P. ; Marusina, Alina I. ; Merleev, Alexander A. ; Wang, Yu ; Pinsker, Bret L. ; Byrd, Angel S. ; Brown, Isabelle D. ; Ravipati, Advaitaa ; Zhang, Emily ; Cai, Shuting S. ; Limjunyawong, Nathachit ; Dong, Xinzhong ; Yeaman, Michael R. ; Simon, Scott I. ; Shen, Wei ; Durum, Scott K. ; O’Brien, Rebecca L. ; Maverakis, Emanual ; Miller, Lloyd S.

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (22), p.10917-10926 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection
Autor: Marchitto, Mark C. ; Dillen, Carly A. ; Liu, Haiyun ; Miller, Robert J. ; Archer, Nathan K. ; Ortines, Roger V. ; Alphonse, Martin P. ; Marusina, Alina I. ; Merleev, Alexander A. ; Wang, Yu ; Pinsker, Bret L. ; Byrd, Angel S. ; Brown, Isabelle D. ; Ravipati, Advaitaa ; Zhang, Emily ; Cai, Shuting S. ; Limjunyawong, Nathachit ; Dong, Xinzhong ; Yeaman, Michael R. ; Simon, Scott I. ; Shen, Wei ; Durum, Scott K. ; O’Brien, Rebecca L. ; Maverakis, Emanual ; Miller, Lloyd S.
Assuntos: Amino acid sequence ; Animals ; Biological Sciences ; Coding ; Complementarity ; Complementarity-determining region ; Complementarity-determining region 3 ; Cytokines ; Disease Models, Animal ; Gene sequencing ; Humans ; IL-1β ; Immunity ; Infections ; Inflammation ; Interleukin 17 ; Interleukin 22 ; Interleukin-17 - physiology ; Lymph nodes ; Lymph Nodes - immunology ; Lymphatic system ; Lymphocytes ; Lymphocytes T ; Mice ; Nodes ; Peptides ; PNAS Plus ; Ribonucleic acid ; RNA ; Skin ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus - pathogenicity ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes - immunology ; Tumor necrosis factor ; γ-Interferon
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (22), p.10917-10926
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: M.C.M., C.A.D., H.L., N.K.A., M.P.A., A.I.M., A.A.M., A.S.B., N.L., X.D., M.R.Y., S.I.S., W.S., S.K.D., R.L.O., E.M., and L.S.M. designed research; M.C.M., C.A.D., H.L., R.J.M., N.K.A., R.V.O., M.P.A., A.I.M., A.A.M., Y.W., B.L.P., A.S.B., I.D.B., A.R., E.Z., S.S.C., N.L., and W.S. performed research; A.I.M., A.A.M., W.S., S.K.D., R.L.O., and E.M. contributed new reagents/analytic tools; M.C.M., C.A.D., H.L., R.J.M., N.K.A., R.V.O., M.P.A., A.I.M., A.A.M., Y.W., B.L.P., A.S.B., I.D.B., A.R., E.Z., S.S.C., N.L., X.D., M.R.Y., S.I.S., W.S., S.K.D., R.L.O., E.M., and L.S.M. analyzed data; and M.C.M., C.A.D., H.L., N.K.A., A.I.M., A.A.M., M.R.Y., S.I.S., S.K.D., R.L.O., E.M., and L.S.M. wrote the paper.
Edited by Rino Rappuoli, GlaxoSmithKline, Siena, Italy, and approved April 18, 2019 (received for review October 31, 2018)
Descrição: T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found that the IL- 17 response was mediated by γδ T cells, which trafficked from lymph nodes to the infected skin to induce neutrophil recruitment, proinflammatory cytokines IL-1α, IL-1β, and TNF, and host defense peptides. RNA-seq for TRG and TRD sequences in lymph nodes and skin revealed a single clonotypic expansion of the encoded complementarity-determining region 3 amino acid sequence, which could be generated by canonical nucleotide sequences of TRGV5 or TRGV6 and TRDV4. However, only TRGV6 and TRDV4 but not TRGV5 sequences expanded. Finally, Vγ6⁺ T cells were a predominant γδ T cell subset that produced IL-17A as well as IL-22, TNF, and IFNγ, indicating a broad and substantial role for clonal Vγ6⁺Vδ4⁺ T cells in immunity against S. aureus skin infections.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

United States: National Academy of Sciences

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