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Reduced expression of the E3-ubiquitin ligase seven in absentia homologue (SIAH)-1 in human hepatocellular carcinoma

Brauckhoff, A ; Ehemann, V ; Schirmacher, P ; Breuhahn, K

Verhandlungen der Deutschen Gesellschaft fur Pathologie, 2007, Vol.91, p.269

Germany

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Título:
Reduced expression of the E3-ubiquitin ligase seven in absentia homologue (SIAH)-1 in human hepatocellular carcinoma
Autor: Brauckhoff, A ; Ehemann, V ; Schirmacher, P ; Breuhahn, K
Assuntos: Antineoplastic Agents - therapeutic use ; Carcinoma, Hepatocellular - enzymology ; Carcinoma, Hepatocellular - genetics ; Drug Design ; Enzyme Inhibitors - therapeutic use ; Gene Expression Regulation, Neoplastic ; Humans ; Liver - enzymology ; Liver Neoplasms - enzymology ; Liver Neoplasms - genetics ; Nuclear Proteins - antagonists & inhibitors ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Protein Binding ; Reference Values ; RNA, Small Interfering - genetics ; Transcription, Genetic ; Ubiquitin-Protein Ligases - antagonists & inhibitors ; Ubiquitin-Protein Ligases - genetics ; Ubiquitin-Protein Ligases - metabolism
É parte de: Verhandlungen der Deutschen Gesellschaft fur Pathologie, 2007, Vol.91, p.269
Descrição: SIAH-1 (seven in absentia homologue-1) is an E3-ubiquitin ligase that facilitates labelling and subsequent proteasomal degradation of different proteins like transcription factors (e.g. c-myb) and coactivators (e.g. beta-catenin). Here we show that SIAH-1 expression is frequently reduced in human hepatocarcinogenesis. However, further reduction of SIAH-1 bioavailability by gene-specific siRNA (RNAinterference) in HCC cell lines resulted in significantly decreased tumor cell viability. Therefore we conclude that distinct SIAH-1 levels mediate pro-tumorigenic effects in HCC cells and that further SIAH-1 inhibition may represent a new therapeutic strategy in the treatment of human hepatocellular carcinoma.
Editor: Germany
Idioma: Alemão

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Reduced expression of the E3-ubiquitin ligase seven in absentia homologue (SIAH)-1 in human hepatocellular carcinoma

Brauckhoff, A ; Ehemann, V ; Schirmacher, P ; Breuhahn, K

Germany

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