Idioma:

The protein expression profile of ACE2 in human tissues

Hikmet, Feria ; Méar, Loren ; Edvinsson, Åsa ; Micke, Patrick ; Uhlén, Mathias ; Lindskog, Cecilia

Molecular systems biology, 2020-07, Vol.16 (7), p.e9610-n/a [Periódico revisado por pares]

England: John Wiley & Sons, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
The protein expression profile of ACE2 in human tissues
Autor: Hikmet, Feria ; Méar, Loren ; Edvinsson, Åsa ; Micke, Patrick ; Uhlén, Mathias ; Lindskog, Cecilia
Assuntos: ACE2 ; Angiotensin ; Angiotensin I ; Angiotensin-Converting Enzyme 2 ; Antibodies ; Betacoronavirus ; Blood ; Blood Vessels - metabolism ; Cardiomyocytes ; Cell surface ; Conjunctiva - metabolism ; Consortia ; Coronaviruses ; Datasets ; Disease transmission ; Enterocytes ; Enterocytes - metabolism ; Female ; Gallbladder ; Gallbladder - metabolism ; Gene expression ; Host Microbial Interactions ; Human tissues ; Humans ; Immunohistochemistry ; Infections ; Kidney Tubules, Proximal - metabolism ; Localization ; Male ; Mass Spectrometry ; Medicin och hälsovetenskap ; mRNA ; Myocytes, Cardiac - metabolism ; Organ Specificity ; Organs ; Pathology ; Patologi ; Peptidyl-Dipeptidase A - genetics ; Peptidyl-Dipeptidase A - metabolism ; Placenta ; Placenta - metabolism ; Pregnancy ; Protein expression ; Proteins ; Proteomics ; Renal tubules ; Respiratory diseases ; Respiratory system ; Respiratory System - metabolism ; RNA-Seq ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Single-Cell Analysis ; Studies ; Testis - metabolism ; transcriptomics ; Trophoblasts ; Viral diseases
É parte de: Molecular systems biology, 2020-07, Vol.16 (7), p.e9610-n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work
Descrição: The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection. Synopsis The protein expression profile of ACE2, suggested as host receptor for SARS‐CoV‐2, is assessed in various human organs. Notably, limited ACE2 expression is observed in the respiratory system both on the protein and mRNA level. Consistent and reliable ACE2 protein expression is found in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye and vasculature. ACE2 expression in the respiratory system is either absent or low in a subset of cells or individuals. The comprehensive summary of ACE expression in all major human tissues and cell types constitutes an important resource for further studies on SARS‐CoV-2 infection and host cell entry. The protein expression profile of ACE2, suggested as host receptor for SARS‐CoV‐2, is assessed in various human organs. Notably, limited ACE2 expression is observed in the respiratory system both on the protein and mRNA level.
Editor: England: John Wiley & Sons, Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

The protein expression profile of ACE2 in human tissues

Hikmet, Feria ; Méar, Loren ; Edvinsson, Åsa ; Micke, Patrick ; Uhlén, Mathias ; Lindskog, Cecilia

England: John Wiley & Sons, Inc

Buscando em bases de dados remotas. Favor aguardar.