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The complexities of the cardiovascular actions of cannabinoids

Randall, Michael D ; Kendall, David A ; O'Sullivan, Saoirse

British journal of pharmacology, 2004-05, Vol.142 (1), p.20-26 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
The complexities of the cardiovascular actions of cannabinoids
Autor: Randall, Michael D ; Kendall, David A ; O'Sullivan, Saoirse
Assuntos: anandamide ; Animals ; Arachidonic Acids - metabolism ; Arachidonic Acids - pharmacology ; Biological and medical sciences ; Cannabinoids ; Cannabinoids - metabolism ; Cannabinoids - pharmacology ; Cardiovascular System - drug effects ; Cardiovascular System - metabolism ; EDHF ; Endocannabinoids ; endothelium ; Humans ; Medical sciences ; Mini Reviews ; Pharmacology. Drug treatments ; Polyunsaturated Alkamides ; sensory nerves ; vanilloid receptors ; Vasodilation - drug effects ; Vasodilation - physiology
É parte de: British journal of pharmacology, 2004-05, Vol.142 (1), p.20-26
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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Descrição: The cardiovascular actions of cannbinoids are complex. In general they cause vasorelaxation in isolated blood vessels, while in anaesthetised animals they cause multiphasic responses which involve an early bradycardia and long‐lasting hypotension. However, in conscious animals, the picture is one of bradycardia followed by pressor responses. Clearly, the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies. In terms of mechanisms involved in the vascular responses to cannabinoids, the following have been implicated: the involvement of ‘classical’ cannabinoid receptors, the involvement of a novel endothelial cannabinoid receptor, the release of nitric oxide, the release of endothelium‐derived hyperpolarising factor (EDHF), the activation of vanilloid receptors, metabolism of endocannabinoids to vasoactive molecules, and both peripheral inhibition and central excitation of the sympathetic nervous system. British Journal of Pharmacology (2004) 142, 20–26. doi:10.1038/sj.bjp.0705725
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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The complexities of the cardiovascular actions of cannabinoids

Randall, Michael D ; Kendall, David A ; O'Sullivan, Saoirse

Oxford, UK: Blackwell Publishing Ltd

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