Idioma:

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors

Reiswich, Viktor ; Gorbokon, Natalia ; Luebke, Andreas M ; Burandt, Eike ; Menz, Anne ; Kluth, Martina ; Hube‐Magg, Claudia ; Wittmer, Corinna ; Weidemann, Sören ; Fraune, Christoph ; Möller, Katharina ; Lebok, Patrick ; Sauter, Guido ; Simon, Ronald ; Uhlig, Ria ; Wilczak, Waldemar ; Jacobsen, Frank ; Minner, Sarah ; Krech, Rainer ; Bernreuther, Christian ; Marx, Andreas ; Steurer, Stefan ; Clauditz, Till ; Krech, Till

The Journal of Pathology: Clinical Research, 2021-11, Vol.7 (6), p.577-589 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
Autor: Reiswich, Viktor ; Gorbokon, Natalia ; Luebke, Andreas M ; Burandt, Eike ; Menz, Anne ; Kluth, Martina ; Hube‐Magg, Claudia ; Wittmer, Corinna ; Weidemann, Sören ; Fraune, Christoph ; Möller, Katharina ; Lebok, Patrick ; Sauter, Guido ; Simon, Ronald ; Uhlig, Ria ; Wilczak, Waldemar ; Jacobsen, Frank ; Minner, Sarah ; Krech, Rainer ; Bernreuther, Christian ; Marx, Andreas ; Steurer, Stefan ; Clauditz, Till ; Krech, Till
Assuntos: Adenocarcinoma ; Alkaline phosphatase ; Alkaline Phosphatase - analysis ; Ampulla of Vater ; Analysis ; Antibodies ; Antigens ; Biomarkers, Tumor - analysis ; Blood Vessels - enzymology ; Blood Vessels - pathology ; Cancer ; Cholangiocarcinoma ; Colorectal cancer ; Colorectal carcinoma ; Endometrial cancer ; Endometrium ; Esophagus ; Fallopian tubes ; Female ; Germany ; GPI-Linked Proteins - analysis ; Humans ; Immunohistochemistry ; Invasiveness ; Isoenzymes - analysis ; Lymphatic Metastasis ; Male ; Metastases ; Neoplasm Invasiveness ; Neoplasm Staging ; Neoplasms - enzymology ; Neoplasms - pathology ; Original ; Pathology ; Phosphatase ; Phosphatases ; Placenta ; Placental alkaline phosphatase ; PLAP ; Predictive Value of Tests ; Seminoma ; Smooth muscle ; Testes ; Tissue Array Analysis ; tissue microarray ; Tumor cells ; Tumors ; Urothelial carcinoma ; Uterus ; Yolk sac
É parte de: The Journal of Pathology: Clinical Research, 2021-11, Vol.7 (6), p.577-589
Notas: Conflict of interest statement: The PLAP antibody clone MSVA‐350R was provided by MS Validated Antibodies GmbH (owned by a family member of GS).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Placental alkaline phosphatase (PLAP) is commonly expressed at high levels in testicular germ cell tumors. PLAP immunohistochemistry (IHC) is thus often used to confirm this diagnosis, especially in cases of putative metastasis. However, other tumors can also express PLAP. To comprehensively determine PLAP expression in normal and tumor tissue, a tissue microarray containing 16,166 samples from 131 different tumor types and subtypes as well as 608 samples from 76 different normal tissue types was analyzed by IHC. Moderate to strong PLAP positivity was found in 27 (21%) of 131 different tumor types including seminoma (96%), embryonal carcinoma (85%), and yolk sac tumors of the testis (56%); endometrioid carcinoma of the endometrium (28%) and the ovary (20%); gastric adenocarcinoma (22%); serous carcinoma (not otherwise specified) of the ovary (17%) and the uterus (11%); adenocarcinoma of the ampulla of Vater (15%); carcinosarcoma of the ovary (11%) and the uterus (8%); esophageal adenocarcinoma (10%); invasive urothelial carcinoma (4%); cholangiocarcinoma (2%); and adenocarcinoma of the lung (1%). Low‐level PLAP immunostaining, often involving only a small fraction of tumor cells, was seen in 21 additional tumor entities. The clinical significance of PLAP expression may vary between tumor types as high PLAP expression was linked to advanced pathological tumor stage (p = 0.0086), nodal metastasis (p = 0.0085), and lymphatic (p = 0.0007) and blood vessel invasion (p = 0.0222) in colorectal cancer, but to low pathological tumor stage in endometrial cancer (p = 0.0043). In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP‐positive metastasis. Low‐level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.
Editor: Hoboken, USA: John Wiley & Sons, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors

Hoboken, USA: John Wiley & Sons, Inc

Buscando em bases de dados remotas. Favor aguardar.