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Effects of bilobalide on γ-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain

Sasaki, Keiko ; Hatta, Shinichi ; Haga, Masanobu ; Ohshika, Hideyo

European journal of pharmacology, 1999-02, Vol.367 (2), p.165-173 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Effects of bilobalide on γ-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain
Autor: Sasaki, Keiko ; Hatta, Shinichi ; Haga, Masanobu ; Ohshika, Hideyo
Assuntos: Animals ; Anticonvulsant activity ; Bilobalide ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Cyclopentanes - pharmacology ; Diterpenes ; Furans - pharmacology ; gamma-Aminobutyric Acid - drug effects ; gamma-Aminobutyric Acid - metabolism ; General pharmacology ; Ginkgo biloba L. ; Ginkgolides ; Glutamate Decarboxylase - drug effects ; Glutamate Decarboxylase - metabolism ; Glutamic Acid - drug effects ; Glutamic Acid - metabolism ; Glutamic acid decarboxylase ; Hippocampus - drug effects ; Hippocampus - metabolism ; Immunoblotting ; Male ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Protein Binding ; Receptors, GABA-A - drug effects ; Receptors, GABA-A - physiology ; Visual Cortex - drug effects ; Visual Cortex - metabolism ; γ-Aminobutyric acid
É parte de: European journal of pharmacology, 1999-02, Vol.367 (2), p.165-173
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SourceType-Scholarly Journals-1
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Descrição: We have previously demonstrated that bilobalide, a constituent of the Ginkgo biloba extract, possesses anticonvulsant activity, and suggested that the mechanism of its anticonvulsant action involves modulation of γ-aminobutyric acid (GABA)-related neuronal transmission. This study examined the effects of bilobalide on the level of GABA and glutamate, the activity and the amount of glutamic acid decarboxylase (EC 4.1.1.15), and the function of GABA A receptors in the hippocampus, cerebral cortex and striatum of the mouse. GABA levels, glutamic acid decarboxylase activity, and the protein amount of 67 kDa glutamic acid decarboxylase in the hippocampus of mice treated with bilobalide (30 mg/kg, p.o., once a day for 4 days) were significantly higher than those in controls. However, there were no significant differences in glutamate levels or, the number and the dissociation constants of GABA A receptors in the hippocampus between control and bilobalide-treated mice. These results suggest that the anticonvulsant effect of bilobalide is due to elevation of GABA levels, possibly through potentiation of glutamic acid decarboxylase activity and enhancement of the protein amount of 67 kDa glutamic acid decarboxylase by bilobalide.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Effects of bilobalide on γ-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain

Sasaki, Keiko ; Hatta, Shinichi ; Haga, Masanobu ; Ohshika, Hideyo

Amsterdam: Elsevier B.V

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