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Enzymatic Vitreolysis with Ocriplasmin for Vitreomacular Traction and Macular Holes

Stalmans, Peter ; Benz, Matthew S ; Gandorfer, Arnd ; Kampik, Anselm ; Girach, Aniz ; Pakola, Stephen ; Haller, Julia A

The New England journal of medicine, 2012-08, Vol.367 (7), p.606-615 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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Título:
Enzymatic Vitreolysis with Ocriplasmin for Vitreomacular Traction and Macular Holes
Autor: Stalmans, Peter ; Benz, Matthew S ; Gandorfer, Arnd ; Kampik, Anselm ; Girach, Aniz ; Pakola, Stephen ; Haller, Julia A
Assuntos: Acuity ; Adhesion ; Adult ; Biological and medical sciences ; Clinical trials ; Diabetic retinopathy ; Double-Blind Method ; Eye ; Eye Diseases - drug therapy ; Fibrinolysin - therapeutic use ; Fibronectin ; General aspects ; Hemorrhage ; Humans ; Injection ; Intravitreal Injections ; Laminin ; Medical sciences ; Ophthalmology ; Pain ; Patients ; Peptide Fragments - therapeutic use ; Retina ; Retina - pathology ; Retinal Perforations - drug therapy ; Retinopathies ; Visual Acuity ; Vitreous Body - pathology
É parte de: The New England journal of medicine, 2012-08, Vol.367 (7), p.606-615
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-News-3
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Descrição: Vitreolysis for Vitreomacular Traction and Macular Holes Intravitreal injection of a modified protease that targets components of the vitreomacular interface resolved vitreomacular traction and closed macular holes more often than did placebo, albeit with associated, mainly transient, ocular adverse events. The human vitreous body is bounded posteriorly by the retina and is variably adherent to it. Collagen fibrils forming the posterior vitreous cortex are firmly attached at the macula, the central part of the retina where visual acuity is best, and are connected to its internal limiting membrane by means of a biochemical glue composed of proteoglycans, including laminin and fibrinectin. 1 – 4 With aging, the gel-like vitreous progressively liquefies and vitreoretinal adhesions weaken, leading to separation of the vitreous from the retina, or posterior vitreous detachment. 5 – 7 Vitreomacular adhesion is observed after partial posterior vitreous detachment, when a portion of . . .
Editor: Waltham, MA: Massachusetts Medical Society
Idioma: Inglês

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Enzymatic Vitreolysis with Ocriplasmin for Vitreomacular Traction and Macular Holes

Stalmans, Peter ; Benz, Matthew S ; Gandorfer, Arnd ; Kampik, Anselm ; Girach, Aniz ; Pakola, Stephen ; Haller, Julia A

Waltham, MA: Massachusetts Medical Society

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