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Challenging the Traditional Paradigm of Supply and Demand in Pediatric Liver Transplantation Through Nondirected Living Donation: A Case Series

Yoeli, Dor ; Jackson, Whitney E. ; Adams, Megan A. ; Wachs, Michael E. ; Sundaram, Shikha S. ; Sater, Anna ; Cisek, Jaime R. ; Choudhury, Rashikh A. ; Nydam, Trevor L. ; Pomposelli, James J. ; Conzen, Kendra D. ; Kriss, Michael S. ; Burton, James R. ; Pomfret, Elizabeth A.

Liver transplantation, 2021-10, Vol.27 (10), p.1392-1400 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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  • Título:
    Challenging the Traditional Paradigm of Supply and Demand in Pediatric Liver Transplantation Through Nondirected Living Donation: A Case Series
  • Autor: Yoeli, Dor ; Jackson, Whitney E. ; Adams, Megan A. ; Wachs, Michael E. ; Sundaram, Shikha S. ; Sater, Anna ; Cisek, Jaime R. ; Choudhury, Rashikh A. ; Nydam, Trevor L. ; Pomposelli, James J. ; Conzen, Kendra D. ; Kriss, Michael S. ; Burton, James R. ; Pomfret, Elizabeth A.
  • Assuntos: Child ; Children ; Graft Survival ; Humans ; Kidneys ; Liver ; Liver transplantation ; Liver Transplantation - adverse effects ; Liver transplants ; Living Donors ; Organ donors ; Pediatrics ; Retrospective Studies
  • É parte de: Liver transplantation, 2021-10, Vol.27 (10), p.1392-1400
  • Notas: Potential conflict of interest: Nothing to report.
    Dor Yoeli, Whitney E. Jackson, James R. Burton Jr., and Elizabeth A. Pomfret were involved in the conception or design of the work. Dor Yoeli, Whitney E. Jackson, Anna Sater, and Jaime R. Cisek were involved in the data acquisition and statistical analysis. Dor Yoeli, Whitney E. Jackson, James R. Burton Jr., and Elizabeth A. Pomfret were involved in the analysis and interpretation of data. Dor Yoeli and Whitney E. Jackson drafted the article. Dor Yoeli, Whitney E. Jackson, Megan A. Adams, Michael E. Wachs, Shikha S. Sundaram, Anna Sater, Jaime R. Cisek, Rashikh A. Choudhury, Trevor L. Nydam, James J. Pomposelli, Kendra D. Conzen, Michael S. Kriss, James R. Burton Jr., and Elizabeth A. Pomfret critically revised the article and approved the version to be published.
    Dor Yoeli and Whitney E. Jackson contributed equally as co‐first authors.
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  • Descrição: A gap exists between the demand for pediatric liver transplantation and the supply of appropriate size‐matched donors. We describe our center’s experience with pediatric liver transplantation using anonymous nondirected living liver donors (ND‐LLD). First‐time pediatric liver transplant candidates listed at our center between January 2012 and June 2020 were retrospectively reviewed and categorized by donor graft type, and recipients of ND‐LLD grafts were described. A total of 13 ND‐LLD pediatric liver transplantations were performed, including 8 left lateral segments, 4 left lobes, and 1 right lobe. Of the ND‐LLD recipients, 5 had no directed living donor evaluated, whereas the remaining 8 (62%) had all potential directed donors ruled out during the evaluation process. Recipient and graft survival were 100% during a median follow‐up time of 445 (range, 70‐986) days. Of ND‐LLDs, 69% were previous living kidney donors, and 1 ND‐LLD went on to donate a kidney after liver donation. Of the ND‐LLDs, 46% were approved prior to the recipient being listed. Over time, the proportion of living donor transplants performed, specifically from ND‐LLDs, increased, and the number of children on the waiting list decreased. The introduction of ND‐LLDs to a pediatric liver transplant program can expand the benefit of living donor liver transplantation to children without a suitable directed living donor while achieving excellent outcomes for both the recipients and donors.
  • Editor: United States: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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