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Association between arterial stiffness and atherosclerosis: The Rotterdam Study

VAN POPELE, Nicole M ; GROBBEE, Diederick E ; BOTS, Michiel L ; ASMAR, Roland ; TOPOUCHIAN, Jirar ; RENEMAN, Robert S ; HOEKS, Arnold P. G ; VAN DER KUIP, Deidre A. M ; HOFMAN, Albert ; WITTEMAN, Jacqueline C. M

Stroke (1970), 2001-02, Vol.32 (2), p.454-460 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Association between arterial stiffness and atherosclerosis: The Rotterdam Study
Autor: VAN POPELE, Nicole M ; GROBBEE, Diederick E ; BOTS, Michiel L ; ASMAR, Roland ; TOPOUCHIAN, Jirar ; RENEMAN, Robert S ; HOEKS, Arnold P. G ; VAN DER KUIP, Deidre A. M ; HOFMAN, Albert ; WITTEMAN, Jacqueline C. M
Assuntos: Age Distribution ; Aged ; Aged, 80 and over ; Aortic Diseases - diagnosis ; Aortic Diseases - epidemiology ; Aortography ; Arteriosclerosis - diagnosis ; Arteriosclerosis - epidemiology ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - epidemiology ; Carotid Artery, Common - diagnostic imaging ; Cohort Studies ; Comorbidity ; Diseases of the aorta ; Female ; Follow-Up Studies ; Heart Rate ; Humans ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Netherlands - epidemiology ; Posture ; Predictive Value of Tests ; Pulsatile Flow ; Reproducibility of Results ; Risk Factors ; Sex Distribution ; Ultrasonography
É parte de: Stroke (1970), 2001-02, Vol.32 (2), p.454-460
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Studies of the association between arterial stiffness and atherosclerosis are contradictory. We studied stiffness of the aorta and the common carotid artery in relation to several indicators of atherosclerosis. This study was conducted within the Rotterdam Study in >3000 elderly subjects aged 60 to 101 years. Aortic stiffness was assessed by measuring carotid-femoral pulse wave velocity, and common carotid artery stiffness was assessed by measuring common carotid distensibility. Atherosclerosis was assessed by common carotid intima-media thickness, plaques in the carotid artery and in the aorta, and the presence of peripheral arterial disease. Data were analyzed by ANCOVA with adjustment for age, sex, mean arterial pressure, and heart rate. Both aortic and common carotid artery stiffness were found to have a strong positive association with common carotid intima-media thickness, severity of plaques in the carotid artery, and severity of plaques in the aorta (P: for trend <0.01 for all associations). Subjects with peripheral arterial disease had significantly increased aortic stiffness (P:=0.001) and borderline significantly increased common carotid artery stiffness (P:=0.08) compared with subjects without peripheral arterial disease. Results were similar after additional adjustment for cardiovascular risk factors and after exclusion of subjects with prevalent cardiovascular disease. This population-based study shows that arterial stiffness is strongly associated with atherosclerosis at various sites in the vascular tree.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Association between arterial stiffness and atherosclerosis: The Rotterdam Study

VAN POPELE, Nicole M ; GROBBEE, Diederick E ; BOTS, Michiel L ; ASMAR, Roland ; TOPOUCHIAN, Jirar ; RENEMAN, Robert S ; HOEKS, Arnold P. G ; VAN DER KUIP, Deidre A. M ; HOFMAN, Albert ; WITTEMAN, Jacqueline C. M

Hagerstown, MD: Lippincott Williams & Wilkins

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