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Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

AlBalwi, Mohammed Ali ; Khan, Anis ; AlDrees, Mohammed ; GK, Udayaraja ; Manie, Balavenkatesh ; Arabi, Yaseen ; Alabdulkareem, Ibrahim ; AlJohani, Sameera ; Alghoribi, Majed ; AlAskar, Ahmed ; AlAjlan, Abdulaziz ; Hajeer, Ali

Journal of infection and public health, 2020-10, Vol.13 (10), p.1544-1550 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Autor: AlBalwi, Mohammed Ali ; Khan, Anis ; AlDrees, Mohammed ; GK, Udayaraja ; Manie, Balavenkatesh ; Arabi, Yaseen ; Alabdulkareem, Ibrahim ; AlJohani, Sameera ; Alghoribi, Majed ; AlAskar, Ahmed ; AlAjlan, Abdulaziz ; Hajeer, Ali
Assuntos: Adult ; Aged ; Amino Acids - genetics ; Coronavirus Infections - virology ; Coronavirus Nucleocapsid Proteins ; Female ; Humans ; Male ; MERS-CoV ; Middle Aged ; Middle East Respiratory Syndrome Coronavirus - genetics ; Mutation ; Nucleocapsid Proteins - genetics ; Original ; Phylogeny ; RNA, Viral - analysis ; SARS-CoV ; Saudi Arabia ; Substitutions ; Virulence - genetics ; Whole Genome Sequencing ; Zoonosis
É parte de: Journal of infection and public health, 2020-10, Vol.13 (10), p.1544-1550
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Middle East respiratory syndrome coronavirus (MERS-CoV) has continued to cause sporadic outbreaks of severe respiratory tract infection over the last 8 years. Complete genome sequencing using next-generation sequencing was performed for MERS-CoV isolates from cases that occurred in Riyadh between 2015 and 2019. Phylogenetic analysis and molecular mutational analysis were carried out to investigate disease severity. A total of eight MERS-CoV isolates were subjected to complete genome sequencing. Phylogenetic analysis resulted in the assembly of 7/8 sequences within lineage 3 and one sequence within lineage 4 showing complex genomic recombination. The isolates contained a variety of unique amino acid substitutions in ORF1ab (41), the N protein (10), the S protein (9) and ORF4b (5). Our study shows that MERS-CoV is evolving. The emergence of new variants carries the potential for increased virulence and could impose a challenge to the global health system. We recommend the sequencing every new MERS-CoV isolate to observe the changes in the virus and relate them to clinical outcomes.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

AlBalwi, Mohammed Ali ; Khan, Anis ; AlDrees, Mohammed ; GK, Udayaraja ; Manie, Balavenkatesh ; Arabi, Yaseen ; Alabdulkareem, Ibrahim ; AlJohani, Sameera ; Alghoribi, Majed ; AlAskar, Ahmed ; AlAjlan, Abdulaziz ; Hajeer, Ali

England: Elsevier Ltd

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