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Synchronized Swarmers and Sticky Stalks: Caulobacter crescentus as a Model for Bacterial Cell Biology

Barrows, Jordan M ; Goley, Erin D O’Toole, George

Journal of bacteriology, 2023-02, Vol.205 (2), p.e0038422-e0038422 [Periódico revisado por pares]

United States: American Society for Microbiology

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  • Título:
    Synchronized Swarmers and Sticky Stalks: Caulobacter crescentus as a Model for Bacterial Cell Biology
  • Autor: Barrows, Jordan M ; Goley, Erin D
  • O’Toole, George
  • Assuntos: Appendages ; Bacterial Proteins - genetics ; Bacteriology ; Biology ; Caulobacter crescentus ; Caulobacter crescentus - metabolism ; Cell Cycle ; Cell differentiation ; Cell Division ; Developmental biology ; Differentiation ; Life cycles ; Localization ; Minireview ; Special Series: The History of Microbial Model Systems
  • É parte de: Journal of bacteriology, 2023-02, Vol.205 (2), p.e0038422-e0038422
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-2
    The authors declare no conflict of interest.
  • Descrição: First isolated and classified in the 1960s, Caulobacter crescentus has been instrumental in the study of bacterial cell biology and differentiation. C. crescentus is a Gram-negative alphaproteobacterium that exhibits a dimorphic life cycle composed of two distinct cell types: a motile swarmer cell and a nonmotile, division-competent stalked cell. Progression through the cell cycle is accentuated by tightly controlled biogenesis of appendages, morphological transitions, and distinct localization of developmental regulators. These features as well as the ability to synchronize populations of cells and follow their progression make C. crescentus an ideal model for answering questions relevant to how development and differentiation are achieved at the single-cell level. This review will explore the discovery and development of C. crescentus as a model organism before diving into several key features and discoveries that have made it such a powerful organism to study. Finally, we will summarize a few of the ongoing areas of research that are leveraging knowledge gained over the last century with C. crescentus to highlight its continuing role at the forefront of cell and developmental biology.
  • Editor: United States: American Society for Microbiology
  • Idioma: Inglês

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