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Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality

Maung, Ko ; Ramalingam, Sendhilnathan ; Chaudhry, Mohammad ; Ren, Yi ; Jung, Sin-Ho ; Romero, Kristi ; Corbet, Kelly ; Chao, Nelson J ; Choi, Taewoong ; Diehl, Anna Mae ; Diehl, Louis ; Gasparetto, Cristina ; Horwitz, Mitchell ; Long, Gwynn Douglas ; Lopez, Richard D ; Rizzieri, David A ; Sarantopoulos, Stefanie ; Sullivan, Keith M ; Bashir, Mustafa R ; Sung, Anthony D Alpini, Gianfranco D.

PloS one, 2020-09, Vol.15 (9), p.e0238824-e0238824 [Periódico revisado por pares]

San Francisco: Public Library of Science

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Título:
Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality
Autor: Maung, Ko ; Ramalingam, Sendhilnathan ; Chaudhry, Mohammad ; Ren, Yi ; Jung, Sin-Ho ; Romero, Kristi ; Corbet, Kelly ; Chao, Nelson J ; Choi, Taewoong ; Diehl, Anna Mae ; Diehl, Louis ; Gasparetto, Cristina ; Horwitz, Mitchell ; Long, Gwynn Douglas ; Lopez, Richard D ; Rizzieri, David A ; Sarantopoulos, Stefanie ; Sullivan, Keith M ; Bashir, Mustafa R ; Sung, Anthony D
Alpini, Gianfranco D.
Assuntos: Abdomen ; Attenuation ; Biology and Life Sciences ; Cancer ; Complications ; Complications and side effects ; Computed tomography ; Cytokines ; Fatty liver ; Graft versus host disease ; Graft versus host reaction ; Graft vs. host disease ; Health care facilities ; Laboratories ; Liver ; Liver diseases ; Liver transplantation ; Liver transplants ; Medicine ; Medicine and Health Sciences ; Metabolic disorders ; Metabolic syndrome ; Microbiota ; Mortality ; Musculoskeletal system ; Obesity ; Patients ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Spleen ; Steatosis ; Stem cells ; Transplantation ; Transplants & implants
É parte de: PloS one, 2020-09, Vol.15 (9), p.e0238824-e0238824
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
Descrição: Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible.
Editor: San Francisco: Public Library of Science
Idioma: Inglês

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Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality

San Francisco: Public Library of Science

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