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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Halfmann, Peter J ; Iida, Shun ; Iwatsuki-Horimoto, Kiyoko ; Maemura, Tadashi ; Kiso, Maki ; Scheaffer, Suzanne M ; Darling, Tamarand L ; Joshi, Astha ; Loeber, Samantha ; Singh, Gagandeep ; Foster, Stephanie L ; Ying, Baoling ; Case, James Brett ; Chong, Zhenlu ; Whitener, Bradley ; Moliva, Juan ; Floyd, Katharine ; Ujie, Michiko ; Nakajima, Noriko ; Ito, Mutsumi ; Wright, Ryan ; Uraki, Ryuta ; Warang, Prajakta ; Gagne, Matthew ; Li, Rong ; Sakai-Tagawa, Yuko ; Liu, Yanan ; Larson, Deanna ; Osorio, Jorge E ; Hernandez-Ortiz, Juan P ; Henry, Amy R ; Ciuoderis, Karl ; Florek, Kelsey R ; Patel, Mit ; Odle, Abby ; Wong, Lok-Yin Roy ; Bateman, Allen C ; Wang, Zhongde ; Edara, Venkata-Viswanadh ; Franks, John ; Jeevan, Trushar ; Fabrizio, Thomas ; DeBeauchamp, Jennifer ; Kercher, Lisa ; Seiler, Patrick ; Gonzalez-Reiche, Ana Silvia ; Sordillo, Emilia Mia ; Chang, Lauren A ; van Bakel, Harm ; Simon, Viviana ; Douek, Daniel C ; Sullivan, Nancy J ; Thackray, Larissa B ; Ueki, Hiroshi ; Yamayoshi, Seiya ; Imai, Masaki ; Perlman, Stanley ; Webby, Richard J ; Seder, Robert A ; Suthar, Mehul S ; García-Sastre, Adolfo ; Schotsaert, Michael ; Suzuki, Tadaki ; Boon, Adrianus C M ; Diamond, Michael S ; Kawaoka, Yoshihiro

Nature (London), 2022-03, Vol.603 (7902), p.687-692 [Periódico revisado por pares]

England: Nature Publishing Group

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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
Autor: Halfmann, Peter J ; Iida, Shun ; Iwatsuki-Horimoto, Kiyoko ; Maemura, Tadashi ; Kiso, Maki ; Scheaffer, Suzanne M ; Darling, Tamarand L ; Joshi, Astha ; Loeber, Samantha ; Singh, Gagandeep ; Foster, Stephanie L ; Ying, Baoling ; Case, James Brett ; Chong, Zhenlu ; Whitener, Bradley ; Moliva, Juan ; Floyd, Katharine ; Ujie, Michiko ; Nakajima, Noriko ; Ito, Mutsumi ; Wright, Ryan ; Uraki, Ryuta ; Warang, Prajakta ; Gagne, Matthew ; Li, Rong ; Sakai-Tagawa, Yuko ; Liu, Yanan ; Larson, Deanna ; Osorio, Jorge E ; Hernandez-Ortiz, Juan P ; Henry, Amy R ; Ciuoderis, Karl ; Florek, Kelsey R ; Patel, Mit ; Odle, Abby ; Wong, Lok-Yin Roy ; Bateman, Allen C ; Wang, Zhongde ; Edara, Venkata-Viswanadh ; Franks, John ; Jeevan, Trushar ; Fabrizio, Thomas ; DeBeauchamp, Jennifer ; Kercher, Lisa ; Seiler, Patrick ; Gonzalez-Reiche, Ana Silvia ; Sordillo, Emilia Mia ; Chang, Lauren A ; van Bakel, Harm ; Simon, Viviana ; Douek, Daniel C ; Sullivan, Nancy J ; Thackray, Larissa B ; Ueki, Hiroshi ; Yamayoshi, Seiya ; Imai, Masaki ; Perlman, Stanley ; Webby, Richard J ; Seder, Robert A ; Suthar, Mehul S ; García-Sastre, Adolfo ; Schotsaert, Michael ; Suzuki, Tadaki ; Boon, Adrianus C M ; Diamond, Michael S ; Kawaoka, Yoshihiro
Assuntos: ACE2 ; Angiotensin-converting enzyme 2 ; Angiotensin-Converting Enzyme 2 - genetics ; Angiotensin-Converting Enzyme 2 - metabolism ; Animal models ; Animals ; Antibodies ; Bronchopulmonary infection ; Coronaviruses ; COVID-19 - pathology ; COVID-19 - virology ; COVID-19 vaccines ; Cricetinae ; Disease Models, Animal ; Female ; Hamsters ; Humans ; Immunocompetence ; Infections ; Infectious diseases ; Laboratories ; Lung - pathology ; Lung - virology ; Lung diseases ; Lungs ; Male ; Mesocricetus ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Pandemics ; Pathogenesis ; Proteins ; Respiratory tract ; Respiratory tract diseases ; Rodents ; SARS-CoV-2 - pathogenicity ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Transgenic animals ; Transgenic mice ; Vaccines ; Viral diseases ; Viral Load ; Viruses ; Weight loss
É parte de: Nature (London), 2022-03, Vol.603 (7902), p.687-692
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The recent emergence of B.1.1.529, the Omicron variant , has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. ), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data.
Editor: England: Nature Publishing Group
Idioma: Inglês

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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

England: Nature Publishing Group

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