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Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis

Diez-Echave, Patricia ; Ruiz-Malagón, Antonio Jesús ; Molina-Tijeras, José Alberto ; Hidalgo-García, Laura ; Vezza, Teresa ; Cenis-Cifuentes, Laura ; Rodríguez-Sojo, María Jesús ; Cenis, José Luis ; Rodríguez-Cabezas, María Elena ; Rodríguez-Nogales, Alba ; Gálvez, Julio ; Lozano-Pérez, Antonio Abel

International journal of pharmaceutics, 2021-09, Vol.606, p.120935-120935, Article 120935 [Periódico revisado por pares]

Elsevier B.V

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  • Título:
    Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis
  • Autor: Diez-Echave, Patricia ; Ruiz-Malagón, Antonio Jesús ; Molina-Tijeras, José Alberto ; Hidalgo-García, Laura ; Vezza, Teresa ; Cenis-Cifuentes, Laura ; Rodríguez-Sojo, María Jesús ; Cenis, José Luis ; Rodríguez-Cabezas, María Elena ; Rodríguez-Nogales, Alba ; Gálvez, Julio ; Lozano-Pérez, Antonio Abel
  • Assuntos: Anti-inflammatory ; Drug loading ; Inflammatory bowel disease ; Quercetin ; Silk fibroin nanoparticles
  • É parte de: International journal of pharmaceutics, 2021-09, Vol.606, p.120935-120935, Article 120935
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: [Display omitted] Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder affecting the gastrointestinal tract. The pharmacological treatments used currently for its treatment lack efficacy, so new therapeutic strategies should be developed. In this context, flavonoids loaded in biopolymeric nanoparticles can be considered as novel promising candidates. The aim of the present study was to evaluate the intestinal anti-inflammatory effects of quercetin when is administered loaded in silk fibroin nanoparticles (QSFN) in the dextran sulphate sodium experimental model of mouse colitis, which displays some similarities to human IBD. Previously characterized quercetin-loaded silk fibroin nanoparticles (QSFN). QSFN showed a reversible aggregation profile induced by the acidification of the solution but did not affect the loaded quercetin. Daily administration of QSFN significantly reduced disease activity index values compared to the control colitic group. This beneficial effect was not only corroborated by the histological examination of the colonic specimens but also the improvement of the colonic expression of the different proinflammatory cytokines (Tnf-α, Il-1β, Il-6, Mcp-1, Icam-1, Nlrp3 and iNOS). Therefore, these data suggest that QSFN could be a promising alternative to current treatments as a drug delivery system for IBD treatment.
  • Editor: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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