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Hair cortisol concentrations in decedents with severe mental illness – An autopsy-based cohort study

Busch, Johannes Rødbro ; Wang, Xin ; Lynnerup, Niels ; Jacobsen, Christina ; Jørgensen, Martin Balslev ; Linnet, Kristian ; Johansen, Sys Stybe ; Banner, Jytte

Forensic Science International. Reports, 2021-07, Vol.3, p.100173, Article 100173 [Periódico revisado por pares]

Elsevier B.V

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  • Título:
    Hair cortisol concentrations in decedents with severe mental illness – An autopsy-based cohort study
  • Autor: Busch, Johannes Rødbro ; Wang, Xin ; Lynnerup, Niels ; Jacobsen, Christina ; Jørgensen, Martin Balslev ; Linnet, Kristian ; Johansen, Sys Stybe ; Banner, Jytte
  • Assuntos: Forensic autopsy ; Hair cortisol ; Physiological hypercortisolemia ; Schizophrenia ; Severe mental illness
  • É parte de: Forensic Science International. Reports, 2021-07, Vol.3, p.100173, Article 100173
  • Descrição: •Severe mental illness is associated with a reduction in life expectancy of up to 20 years.•Some of this excess mortality may be due to chronic physiological hypercortisolemia.•Hair cortisol concentrations may be a useful biomarker for measuring average levels of cortisol over longer time.•We found no association between psychiatric diagnosis and hair cortisol levels.•Hair cortisol was elevated in patients with a history of a prescription for either SSRI and/or benzodiazepine drugs. Severe mental illness (SMI) is associated with a marked increase in mortality, both from natural and unnatural causes. Patients may be subject to accelerated aging and an increased disposition for developing chronic somatic disease. One possible contributory cause to this may be chronic hyperactivity of the hypothalamus-pituitary-adrenal (HPA)-axis and subsequent increased levels of cortisol. This study analyzed hair cortisol concentrations (HCC) using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) in hair samples from forensic autopsies of patients with SMI, validated via health registry data. Results: HCC was not associated with a particular diagnosis or increased in patients compared with decedents without SMI. HCC was higher in decedents who had been prescribed psychotropic medication, especially SSRI and benzodiazepines. HCC was not associated with a history of coerced admissions or high number of days of admission. Future studies evaluating HCC as a proxy marker for stress should consider including medication history as a covariate. Reference ranges for healthy adults using standardized methods are needed in order to provide better interpretation of patient HCC.
  • Editor: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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