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Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study

Cable, Ritchard G. ; Glynn, Simone A. ; Kiss, Joseph E. ; Mast, Alan E. ; Steele, Whitney R. ; Murphy, Edward L. ; Wright, David J. ; Sacher, Ronald A. ; Gottschall, Jerry L. ; Vij, Vibha ; Simon, Toby L.

Transfusion (Philadelphia, Pa.), 2011-03, Vol.51 (3), p.511-522 [Periódico revisado por pares]

Malden, USA: Blackwell Publishing Inc

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Título:
Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study
Autor: Cable, Ritchard G. ; Glynn, Simone A. ; Kiss, Joseph E. ; Mast, Alan E. ; Steele, Whitney R. ; Murphy, Edward L. ; Wright, David J. ; Sacher, Ronald A. ; Gottschall, Jerry L. ; Vij, Vibha ; Simon, Toby L.
Assuntos: Adult ; Age ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Donors ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; demography ; Diets ; Ethnic groups ; Female ; Ferritins - blood ; Hematology ; Hemoglobins - analysis ; Historical account ; Humans ; Ingestion ; Investigative techniques, diagnostic techniques (general aspects) ; Iron ; Iron - deficiency ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pregnancy ; Receptors, Transferrin - blood ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy
É parte de: Transfusion (Philadelphia, Pa.), 2011-03, Vol.51 (3), p.511-522
Notas: istex:5B0777460B3264CB548BC4F22F340DDF0CC3F861
ArticleID:TRF2865
ark:/67375/WNG-JCHG9KMN-3
This work was supported by NHLBI contracts N01‐HB‐47168, ‐47169, ‐47171, ‐47172, ‐47174, and ‐47175.
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Descrição: BACKGROUND: Regular blood donors are at risk of iron deficiency, but characteristics that predispose to this condition are poorly defined. STUDY DESIGN AND METHODS: A total of 2425 red blood cell donors, either first‐time (FT) or reactivated donors (no donations for 2 years) or frequent donors, were recruited for follow‐up. At enrollment, ferritin, soluble transferrin receptor (sTfR), and hemoglobin were determined. Donor variables included demographics, smoking, dietary intake, use of iron supplements, and menstrual and/or pregnancy history. Models to predict two measures of iron deficiency were developed: Absent iron stores (AIS) were indicated by a ferritin level of less than 12 ng/mL and iron‐deficient erythropoiesis (IDE) by a log(sTfR/ferritin) value of 2.07 or greater. RESULTS: A total of 15.0% of donors had AIS and 41.7% IDE. In frequent donors, 16.4 and 48.7% of males had AIS and IDE, respectively, with corresponding proportions of 27.1 and 66.1% for females. Donation intensity was most closely associated with AIS and/or IDE (odds ratios from 5.3 to 52.2 for different donation intensity compared to FT donors). Being female, younger, and/or menstruating also increased the likelihood of having AIS and/or IDE, as did having a lower weight. Marginally significant variables for AIS and/or IDE were being a nonsmoker, previous pregnancy, and not taking iron supplements. Dietary variables were in general unrelated to AIS and/or IDE, as was race and/or ethnicity. CONCLUSION: A large proportion of both female and male frequent blood donors have iron depletion. Donation intensity, sex and/or menstrual status, weight, and age are important independent predictors of AIS and/or IDE. Reducing the frequency of blood donation is likely to reduce the prevalence of iron deficiency among blood donors, as might implementing routine iron supplementation.
Editor: Malden, USA: Blackwell Publishing Inc
Idioma: Inglês

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Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study

Cable, Ritchard G. ; Glynn, Simone A. ; Kiss, Joseph E. ; Mast, Alan E. ; Steele, Whitney R. ; Murphy, Edward L. ; Wright, David J. ; Sacher, Ronald A. ; Gottschall, Jerry L. ; Vij, Vibha ; Simon, Toby L.

Malden, USA: Blackwell Publishing Inc

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