Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro­[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)­bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, Angelo ; Lu, Jianfeng ; Liu, Liu ; Du, Ding ; Bernard, Denzil ; McEachern, Donna ; Przybranowski, Sally ; Li, Xiaoqin ; Luo, Ruijuan ; Wen, Bo ; Sun, Duxin ; Wang, Hengbang ; Wen, Jianfeng ; Wang, Guangfeng ; Zhai, Yifan ; Guo, Ming ; Yang, Dajun ; Wang, Shaomeng

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2819-2839 [Periódico revisado por pares]

United States: American Chemical Society

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