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Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Graff, Mariaelisa ; Scott, Robert A ; Young, Kristin L ; Winkler, Thomas W ; Chu, Audrey Y ; den Hoed, Marcel ; Ahluwalia, Tarunveer S ; Quaye, Lydia ; Eicher, John D ; Hayes, James E ; Kutalik, Zoltan ; Lim, Elise ; Luan, Jian'an ; Haller, Toomas ; Bien, Stephanie ; Teumer, Alexander ; Kleber, Marcus E ; Rivera, Natalia V ; Zhao, Jing Hua ; Stringham, Heather M ; Lyytikäinen, Leo-Pekka ; Huppertz, Charlotte ; Peyrot, Wouter J ; Wu, Ying ; Fornage, Myriam ; Hassinen, Maija ; Cadby, Gemma ; Jackson, Anne U ; Bragg-Gresham, Jennifer L ; Marten, Jonathan ; Bellis, Claire ; Pasko, Dorota ; Cheng, Yu-Ching ; Eriksson, Joel ; Aadahl, Mette ; Adair, Linda S ; Balkau, Beverley ; Bergmann, Sven ; Borja, Judith B ; Chines, Peter S ; Corre, Tanguy ; Dueker, Nicole ; Eiriksdottir, Gudny ; Esko, Tõnu ; Grammer, Tanja B ; Hernandez, Dena ; Hui, Jennie ; James, Alan L ; Jhun, Min A ; Juonala, Markus ; Launer, Lenore J ; Lindgren, Cecilia M ; Lorentzon, Mattias ; Luben, Robert ; Marre, Michel ; Milaneschi, Yuri ; Narisu, Narisu ; Nauck, Matthias ; Nolte, Ilja M ; Oldehinkel, Albertine J ; Peyser, Patricia A ; Rawal, Rajesh ; Ridker, Paul M ; Rose, Lynda M ; Sarzynski, Mark A ; Snieder, Harold ; Stančáková, Alena ; Sternfeld, Barbara ; Swift, Amy J ; van Vliet-Ostaptchouk, Jana V ; Vohl, Marie-Claude ; Waeber, Gérard ; Walker, Mark ; Wild, Sarah ; Wright, Alan F ; Lemarchand, Loic ; Hofman, Albert ; Rivadeneira, Fernando ; Pérusse, Louis ; Wilson, James F ; Hayward, Caroline ; Hartman, Catharina A ; Tönjes, Anke ; Kardia, Sharon L R ; Salomaa, Veikko ; Penninx, Brenda W J H ; Laakso, Markku ; März, Winfried ; Kooner, Jaspal S ; Hallmans, Göran ; Hansen, Torben ; Metspalu, Andres ; Weir, David R ; Boerwinkle, Eric ; Chasman, Daniel I ; O'Connell, Jeffrey R ; Mohlke, Karen L ; Liu, Ching-Ti ; Hirschhorn, Joel N ; Loos, Ruth J F Edwards, Todd L.

PLoS genetics, 2017-04, Vol.13 (4), p.e1006528 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults
Autor: Graff, Mariaelisa ; Scott, Robert A ; Young, Kristin L ; Winkler, Thomas W ; Chu, Audrey Y ; den Hoed, Marcel ; Ahluwalia, Tarunveer S ; Quaye, Lydia ; Eicher, John D ; Hayes, James E ; Kutalik, Zoltan ; Lim, Elise ; Luan, Jian'an ; Haller, Toomas ; Bien, Stephanie ; Teumer, Alexander ; Kleber, Marcus E ; Rivera, Natalia V ; Zhao, Jing Hua ; Stringham, Heather M ; Lyytikäinen, Leo-Pekka ; Huppertz, Charlotte ; Peyrot, Wouter J ; Wu, Ying ; Fornage, Myriam ; Hassinen, Maija ; Cadby, Gemma ; Jackson, Anne U ; Bragg-Gresham, Jennifer L ; Marten, Jonathan ; Bellis, Claire ; Pasko, Dorota ; Cheng, Yu-Ching ; Eriksson, Joel ; Aadahl, Mette ; Adair, Linda S ; Balkau, Beverley ; Bergmann, Sven ; Borja, Judith B ; Chines, Peter S ; Corre, Tanguy ; Dueker, Nicole ; Eiriksdottir, Gudny ; Esko, Tõnu ; Grammer, Tanja B ; Hernandez, Dena ; Hui, Jennie ; James, Alan L ; Jhun, Min A ; Juonala, Markus ; Launer, Lenore J ; Lindgren, Cecilia M ; Lorentzon, Mattias ; Luben, Robert ; Marre, Michel ; Milaneschi, Yuri ; Narisu, Narisu ; Nauck, Matthias ; Nolte, Ilja M ; Oldehinkel, Albertine J ; Peyser, Patricia A ; Rawal, Rajesh ; Ridker, Paul M ; Rose, Lynda M ; Sarzynski, Mark A ; Snieder, Harold ; Stančáková, Alena ; Sternfeld, Barbara ; Swift, Amy J ; van Vliet-Ostaptchouk, Jana V ; Vohl, Marie-Claude ; Waeber, Gérard ; Walker, Mark ; Wild, Sarah ; Wright, Alan F ; Lemarchand, Loic ; Hofman, Albert ; Rivadeneira, Fernando ; Pérusse, Louis ; Wilson, James F ; Hayward, Caroline ; Hartman, Catharina A ; Tönjes, Anke ; Kardia, Sharon L R ; Salomaa, Veikko ; Penninx, Brenda W J H ; Laakso, Markku ; März, Winfried ; Kooner, Jaspal S ; Hallmans, Göran ; Hansen, Torben ; Metspalu, Andres ; Weir, David R ; Boerwinkle, Eric ; Chasman, Daniel I ; O'Connell, Jeffrey R ; Mohlke, Karen L ; Liu, Ching-Ti ; Hirschhorn, Joel N ; Loos, Ruth J F
Edwards, Todd L.
Assuntos: activity questionnaires ; adipocyte differentiation ; Adipocytes ; Adipose tissue ; Adiposity - genetics ; Adiposity - physiology ; Adults ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics ; Amyotrophic lateral sclerosis ; Analysis ; association metaanalysis ; Basic Medicine ; binding protein ; Biology ; Biology and Life Sciences ; Body Mass Index ; Clinical Medicine ; Diabetes ; Endocrinology ; Environmental factors ; Epidemiology ; Epigenomics ; Exercise ; fat distribution ; Female ; food-intake ; Fto gene ; Gene expression ; Genetic Predisposition to Disease ; Genetics ; Genetics & Heredity ; Genome-Wide Association Study ; Genomes ; Genotype ; Health aspects ; Health care ; Health Sciences ; Heart ; Hip ; Hospitals ; Humans ; Hälsovetenskap ; identical-twins ; Internal medicine ; Kinases ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical Genetics ; Medical research ; Medicin och hälsovetenskap ; Medicine and Health Sciences ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; Meta-analysis ; Metabolic syndrome ; Mutation ; Obesity ; Obesity - genetics ; Obesity - physiopathology ; Physical activity ; Physical fitness ; Physical Sciences ; Physiotherapy ; Population ; Preventive medicine ; Proteins ; Public health ; reactive protein-levels ; Research and Analysis Methods ; Sjukgymnastik ; Transcription factors ; Waist Circumference ; Waist-Hip Ratio ; Womens health
É parte de: PLoS genetics, 2017-04, Vol.13 (4), p.e1006528
Notas: These authors jointly supervised this work.
We have read the journal's policy and the authors of this manuscript have the following competing interests: Genotyping in the Ely and Fenland studies was supported in part by an MRC-GlaxoSmithKline pilot programme grant (G0701863). The RISC Study was supported in part by AstraZeneca. The D.E.S.I.R. study has been supported in part by INSERM contracts with Lilly, Novartis Pharma, Sanofi-Aventis, Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Santé, Novo Nordisk, Pierre Fabre, Roche, and Topcon. In SHIP, genome-wide data have been supported in part by a joint grant from Siemens Healthcare, Erlangen, Germany.
Membership is listed in the Supporting Information.
Conceptualization: TOK RJFL.Data curation: TOK LAC RJFL KLMon.Formal analysis: RAS KLY AEJ TWW AMa DHa NLHC JSN TSA LQ TW FRe MdH TOK QQ MG TSA LX AYC LAC MC RJFL MFF KEN JDE ADJ JEHa RJK.Investigation: AVS TBH GE LJL VG KEN MG AJ KLMon KLY EB PGL JBW NGM GWM DPS GC LJP JHua AWM ALJ JB MFo CBe HMS TR SSn BS YW JBB LSA ZK PMMV TC SBi GWi PV KKr ASH KHa SM VS MP JM IR CHup VV IK OPo LY DT BB MMar AB PF RRaw TAL PK MHo KSa RMag THal TEb AMa JL RAS SBr NJW JHZ RL SBu AD NA CMvD IBB MFF LB RJFL LX NLHC EL JP PJG CSF CTL LAC MB FSC KLMol RNB JT LK TEs HP CS HAK LFB SLRK MAJ PAP SA FRe IB GH PWF JE CO MLo AEJ JOJ TSA LPa GDS TIAS JEHu DJP SP LJH BHS SSa YCC MFu JRO ARS MHa MA AL HVe LQu THu QQ JAS JDF WZhan DRW KHv OLH AUJ LLB AJS KKv TTan DHe SBa MNH JMJ KF NG OPe TWW IMH MO CG HG AP KSt CHo CHut RRau BT MMN WZhao BL WRS STT JCC JSK MEK GED TBG GS JHui WM UL CHa LL LH KL AGB LJRT JAN YL MLa JK AS PSC NN WJP GvG YM BWJHP AMu CML MIM TTam JA MRJ LQi THan DK KKO AW ÅJ UG EJCdG MHMdM JJH DIB GWa PN AFW NDH SW HC JFW CBo MCV LPe DP MW TMF NVR MCZ FRi AH AGU JLBG SSi FB AMe GRA FC ATe HVo UV MD SG MN RMan IP ATo PJvdM JVvVO IMN HS AJO CAH MMan DIC AYC LMR PMR SBi NZ JG UP CK MKu MKi CL LPL NHK MJ MKä OTR TL.Supervision: GRA IB MB IBB CSF TMF IMH RJFL MIM KLMon KEN JRO DPS CMvD JNH.Writing – original draft: MG RAS AEJ KLY MFF LB LQu PWF RJFL TOK.Writing – review & editing: MG RAS AEJ KLY MFF TWW LB AYC AMa DHa LX TW NLHC TSA MdH QQ JSN FRe LQu JDE JEHa MC ZK EL JL JEHu WZhan WZhao PJG THal SA PMMV SBi LY ATe AVS MKu MNH JMJ MEK MHo NVR JBW JHZ HS LL CHup GWi WJP YW KKr AD KL YL MFo MHa LFB GC TTan RMag PJvdM AUJ JLBG VV JM PN CBe DP ÅJ SSn YCC JE UL MA LSA NA BB JA JB RNB AGB JB AB LLB JBB SBr FB SBu HC PSC FSC TC GDS GED ND MD TEb GE TEs JDF MFu KF CG SG JG PGL HG TBG NG GvG THu KHa NDH ASH DHe LH LJH OLH CHo JJH JHua THan JHui CHut NHK ALJ JOJ MAH MJ LK HAK IK PK JK KKv MKa TAL LJL BL CML MLo RL MMar YM KLMon GWM MHMdM AMu AMe RMan SM NN MN JAN IMN AJO MO KKO SP LPa JP MP AP UP PAP IP HP OTR TR LJRT RRaw PMR LMR IR CS MAS KSa WRS SSa ARS SSi GS BHS JAS HS AS BS AJS TTam STT BT DT LV HVe JVvVO MCV UV GWa MW SW AW AFW MCZ NZ CAHai LL UG CO AH FRi AGU LPe JFW CHa OPo FC KHv CAHar ATo SBa LJP SLRK RRau TIAS JT VS BWJHP EJCdG DIB TL MMan MLa CBo NGM DK AL WM KSt MKi TBH VG HVo LQi MRJ JCC JSK PF CK PV GH OPe NJW CL DRW DJP EB DIC GRA IB MIM TMF JRO CMvD MB IMH KLMol DPS CSF CTL JNH RJK ADJ IBB PWF KEN LAC RJFL TOK.
Descrição: Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Editor: United States: Public Library of Science
Idioma: Inglês

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Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

United States: Public Library of Science

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