Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic

Shurtleff, Valerie W. ; Layton, Mark E. ; Parish, Craig A. ; Perkins, James J. ; Schreier, John D. ; Wang, Yunyi ; Adam, Gregory C. ; Alvarez, Nadine ; Bahmanjah, Soheila ; Bahnck-Teets, Carolyn M. ; Boyce, Christopher W. ; Burlein, Christine ; Cabalu, Tamara D. ; Campbell, Brian T. ; Carroll, Steven S. ; Chang, Wonsuk ; de Lera Ruiz, Manuel ; Dolgov, Enriko ; Fay, John F. ; Fox, Nicholas G. ; Goh, Shih Lin ; Hartingh, Timothy J. ; Hurzy, Danielle M. ; Kelly, Michael J. ; Klein, Daniel J. ; Klingler, Franca-Maria ; Krishnamurthy, Harini ; Kudalkar, Shalley ; Mayhood, Todd W. ; McKenna, Philip M. ; Murray, Edward M. ; Nahas, Debbie ; Nawrat, Christopher C. ; Park, Steven ; Qian, Dongming ; Roecker, Anthony J. ; Sharma, Vijeta ; Shipe, William D. ; Su, Jing ; Taggart, Robert V. ; Truong, Quang ; Wu, Yin ; Zhou, Xiaoyan ; Zhuang, Ningning ; Perlin, David S. ; Olsen, David B. ; Howe, John A. ; McCauley, John A.

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3935-3958 [Periódico revisado por pares]

United States: American Chemical Society

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