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EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis

ZHANG, S ; WANG, X ; NELSON, P. S ; WANG, Y. A ; WANG, R ; SHIN, D. M ; MARSHALL, F. F ; KUCUK, O ; CHUNG, Lwk ; ZHAU, H. E ; WU, D ; OSUNKOYA, A. O ; IQBAL, S ; WANG, Y ; CHEN, Z ; MÜLLER, S ; CHEN, Z ; JOSSON, S ; COLEMAN, I. M

Oncogene, 2011-12, Vol.30 (50), p.4941-4952 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis
Autor: ZHANG, S ; WANG, X ; NELSON, P. S ; WANG, Y. A ; WANG, R ; SHIN, D. M ; MARSHALL, F. F ; KUCUK, O ; CHUNG, Lwk ; ZHAU, H. E ; WU, D ; OSUNKOYA, A. O ; IQBAL, S ; WANG, Y ; CHEN, Z ; MÜLLER, S ; CHEN, Z ; JOSSON, S ; COLEMAN, I. M
Assuntos: Actin ; Adherens junctions ; Adherens Junctions - metabolism ; Adherens Junctions - pathology ; beta Catenin - metabolism ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Care and treatment ; catenin ; Cell migration ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cellular biology ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Cytoskeletal Proteins - biosynthesis ; Cytoskeleton ; Down-Regulation ; Epithelial-Mesenchymal Transition ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Gynecology. Andrology. Obstetrics ; Head and neck carcinoma ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - pathology ; Humans ; Immunohistochemistry ; Invasiveness ; Lymph nodes ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Lymphatic system ; Male ; Male genital diseases ; Medical sciences ; Mesenchyme ; Metastases ; Metastasis ; Molecular and cellular biology ; Molecular modelling ; Neoplasm Invasiveness ; Neoplasm Proteins - biosynthesis ; Nephrology. Urinary tract diseases ; Physiological aspects ; Prognosis ; Prostate cancer ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Proteomics ; Signal Transduction ; Solid tumors ; Squamous cell carcinoma ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; β-Catenin
É parte de: Oncogene, 2011-12, Vol.30 (50), p.4941-4952
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Descrição: Epithelial-mesenchymal transition (EMT) is a crucial mechanism for the acquisition of migratory and invasive capabilities by epithelial cancer cells. By conducting quantitative proteomics in experimental models of human prostate cancer (PCa) metastasis, we observed strikingly decreased expression of EPLIN (epithelial protein lost in neoplasm; or LIM domain and actin binding 1, LIMA-1) upon EMT. Biochemical and functional analyses demonstrated that EPLIN is a negative regulator of EMT and invasiveness in PCa cells. EPLIN depletion resulted in the disassembly of adherens junctions, structurally distinct actin remodeling and activation of β-catenin signaling. Microarray expression analysis identified a subset of putative EPLIN target genes associated with EMT, invasion and metastasis. By immunohistochemistry, EPLIN downregulation was also demonstrated in lymph node metastases of human solid tumors including PCa, breast cancer, colorectal cancer and squamous cell carcinoma of the head and neck. This study reveals a novel molecular mechanism for converting cancer cells into a highly invasive and malignant form, and has important implications in prognosis and treating metastasis at early stages.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis

ZHANG, S ; WANG, X ; NELSON, P. S ; WANG, Y. A ; WANG, R ; SHIN, D. M ; MARSHALL, F. F ; KUCUK, O ; CHUNG, Lwk ; ZHAU, H. E ; WU, D ; OSUNKOYA, A. O ; IQBAL, S ; WANG, Y ; CHEN, Z ; MÜLLER, S ; CHEN, Z ; JOSSON, S ; COLEMAN, I. M

Basingstoke: Nature Publishing Group

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