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Pediatric Metabolic Syndrome Predicts Adulthood Metabolic Syndrome, Subclinical Atherosclerosis, and Type 2 Diabetes Mellitus but Is No Better Than Body Mass Index Alone: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study

MAGNUSSEN, Costan G ; KOSKINEN, Juha ; TAITTONEN, Leena ; RÖNNEMAA, Tapani ; VIIKARI, Jorma S. A ; BERENSON, Gerald S ; JUONALA, Markus ; RAITAKARI, Olli T ; WEI CHEN ; THOMSON, Russell ; SCHMIDT, Michael D ; SRINIVASAN, Sathanur R ; KIVIMÄKI, Mika ; MATTSSON, Noora ; KÄHÖNEN, Mika ; LAITINEN, Tomi

Circulation (New York, N.Y.), 2010-10, Vol.122 (16), p.1604-1611 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Pediatric Metabolic Syndrome Predicts Adulthood Metabolic Syndrome, Subclinical Atherosclerosis, and Type 2 Diabetes Mellitus but Is No Better Than Body Mass Index Alone: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study
Autor: MAGNUSSEN, Costan G ; KOSKINEN, Juha ; TAITTONEN, Leena ; RÖNNEMAA, Tapani ; VIIKARI, Jorma S. A ; BERENSON, Gerald S ; JUONALA, Markus ; RAITAKARI, Olli T ; WEI CHEN ; THOMSON, Russell ; SCHMIDT, Michael D ; SRINIVASAN, Sathanur R ; KIVIMÄKI, Mika ; MATTSSON, Noora ; KÄHÖNEN, Mika ; LAITINEN, Tomi
Assuntos: Adolescent ; Adult ; Aging ; Associated diseases and complications ; Atherosclerosis - epidemiology ; Atherosclerosis - ethnology ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Mass Index ; Cardiology. Vascular system ; Child ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes. Impaired glucose tolerance ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Finland - epidemiology ; Follow-Up Studies ; Humans ; Incidence ; Male ; Medical sciences ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - ethnology ; Obesity - complications ; Overweight - complications ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography ; Young Adult
É parte de: Circulation (New York, N.Y.), 2010-10, Vol.122 (16), p.1604-1611
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The clinical utility of identifying pediatric metabolic syndrome (MetS) is controversial. This study sought to determine the status of pediatric MetS as a risk factor for adult subclinical atherosclerosis (carotid intima-media thickness [cIMT]) and type 2 diabetes mellitus (T2DM) and compare and contrast this prediction with its individual components. Using data from the population-based, prospective, observational Bogalusa Heart and Cardiovascular Risk in Young Finns studies, we examined the utility of 4 categorical definitions of youth MetS and their components in predicting adult high cIMT and T2DM among 1781 participants aged 9 to 18 years at baseline (1984 to 1988) who were then examined 14 to 27 years later (2001-2007) when aged 24 to 41 years. Youth with MetS were at 2 to 3 times the risk of having high cIMT and T2DM as adults compared with those free of MetS at youth. Risk estimates with the use of high body mass index were similar to those of MetS phenotypes in predicting adult outcomes. Comparisons of area under the receiver operating characteristic curve and net reclassification index suggested that prediction of adult MetS, high cIMT, and T2DM in adulthood with the use of youth MetS was either equivalent or inferior to classification based on high body mass index or overweight and obesity. Youth with MetS are at increased risk of meaningful adult outcomes; however, the simplicity of screening for high BMI or overweight and obesity in the pediatric setting offers a simpler, equally accurate alternative to identifying youth at risk of developing adult MetS, high cIMT, or T2DM.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Pediatric Metabolic Syndrome Predicts Adulthood Metabolic Syndrome, Subclinical Atherosclerosis, and Type 2 Diabetes Mellitus but Is No Better Than Body Mass Index Alone: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study

Hagerstown, MD: Lippincott Williams & Wilkins

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