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Alcohol and Health: Standards of Consumption, Benefits and Harm – a Review

Isabela Maria Monteiro Vieira Brenda Lohanny Passos Santos; Denise dos Santos Ruzene; Tomas Branyik; Jose Antonio Teixeira; João Batista Almeida e Silva; Daniel Pereira da Silva

Czech journal of food sciences v.36, n.6, p.427-440, 2019

Praga 2019

Item não circula. Consulte sua biblioteca.(Acessar)

  • Título:
    Alcohol and Health: Standards of Consumption, Benefits and Harm – a Review
  • Autor: Isabela Maria Monteiro Vieira
  • Brenda Lohanny Passos Santos; Denise dos Santos Ruzene; Tomas Branyik; Jose Antonio Teixeira; João Batista Almeida e Silva; Daniel Pereira da Silva
  • Assuntos: ABUSO DE ÁLCOOL; BEBIDAS ALCOÓLICAS; Moderate Drinking; Human Health; Patterns Of Consumption; Standard Dose
  • É parte de: Czech journal of food sciences v.36, n.6, p.427-440, 2019
  • Notas: Disponível em: https://doi.org/10.17221/117/2018-CJFS. Acesso em: 06 set. 2022.
  • Descrição: The research on alternative solvents and cosolvents is relevant when envisioning the improvement of biocatalytic reactions. Among these solvents and cosolvents, deep eutectic solvents (DES) may be considered as customizable new reaction media for biocatalysis. Accordingly, in this work, 16 DES aqueous solutions, as well as the individual DES components at the same conditions, have been investigated in laccase-catalyzed reactions. Cholinium- and betaine-based DES formed with polyols at different molar ratios and concentrations were evaluated. The results reported show that in the presence of most DES the laccase activity is preserved and, with a particular DES, enhanced up to 200%. Molecular docking studies demonstrated that while most DES components establish hydrogen bonds with the enzyme amino acids, those that establish stronger interactions with the enzyme (expressed by absolute values of docking affinity energies) lead to an enhanced laccase activity. Finally, the laccase stability was evaluated in additional tests under extreme storage temperatures (60 °C and −80 °C). Although no significant protection to high temperatures was afforded by DES, an enhanced laccase activity when stored at low temperatures was found, at least up to 20 days. Combining experimental results and molecular docking, this work shows that DES can be designed as cosolvents to improve biocatalytic reactions.
  • Editor: Praga
  • Data de criação/publicação: 2019
  • Formato: p. 427-440.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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