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Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis
Gray, Peter C. ; Vale, Wylie
FEBS letters, 2012-07, Vol.586 (14), p.1836-1845
[Periódico revisado por pares]
England: Elsevier B.V
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Título:
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis
Autor:
Gray, Peter C.
;
Vale, Wylie
Assuntos:
Animals
;
BMP
;
bone morphogenetic protein
;
Cancer
;
Cell Membrane - metabolism
;
Cripto
;
Endoplasmic Reticulum Chaperone BiP
;
fibroblast growth factor (FGF) receptor ligand-1
;
FRL-1
;
GDF
;
Gene Expression Regulation, Developmental
;
Gene Expression Regulation, Neoplastic
;
glcyosylphosphatidylinositol
;
glucose regulated protein 78 kDa
;
GPI
;
GPI-Linked Proteins - metabolism
;
growth and differentiation factor
;
GRP78
;
Heat-Shock Proteins - metabolism
;
Humans
;
Intercellular Signaling Peptides and Proteins - metabolism
;
Mice
;
Models, Biological
;
Neoplasm Proteins - metabolism
;
Neoplasms - metabolism
;
Plasticity
;
Protein Structure, Tertiary
;
Signal Transduction
;
Stem cell
;
Stem Cells - cytology
;
TDGF1
;
teratocarcinoma-derived growth factor 1
;
TGF-β
;
Transforming Growth Factor beta - metabolism
É parte de:
FEBS letters, 2012-07, Vol.586 (14), p.1836-1845
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
Descrição:
Cripto is a small, GPI-anchored signaling protein that regulates cellular survival, proliferation, differentiation and migration during normal developmental processes and tumorigenesis. Cripto functions as an obligatory co-receptor for the TGF-β ligands Nodal, GDF1 and GDF3 but attenuates signaling of others such as activin-A, activin-B and TGF-β1. Soluble, secreted forms of Cripto also activate Src, ras/raf/MAPK and PI3K/Akt pathways via a mechanism that remains largely obscure. This review describes the biological roles and signaling mechanisms of Cripto, highlighting our identification of the 78 kDa glucose regulated protein (GRP78) as a cell surface receptor/co-factor required for Cripto signaling via both TGF-β and Src/MAPK/PI3K pathways. We discuss emerging evidence indicating that Cripto/GRP78 signaling regulates normal somatic stem cells and their tumorigenic counterparts.
Editor:
England: Elsevier B.V
Idioma:
Inglês
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