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Adrenal insufficiency

Charmandari, Evangelia, Dr ; Nicolaides, Nicolas C, MD ; Chrousos, George P, Prof

The Lancet (British edition), 2014-06, Vol.383 (9935), p.2152-2167 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
Adrenal insufficiency
Autor: Charmandari, Evangelia, Dr ; Nicolaides, Nicolas C, MD ; Chrousos, George P, Prof
Assuntos: Adrenal glands ; Adrenal Insufficiency - diagnosis ; Adrenal Insufficiency - etiology ; Adrenal Insufficiency - therapy ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Biological and medical sciences ; Endocrinology ; Endocrinopathies ; Female ; General aspects ; Hormones ; Humans ; Internal Medicine ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Plasma ; Pregnancy ; Pregnancy Complications
É parte de: The Lancet (British edition), 2014-06, Vol.383 (9935), p.2152-2167
Notas: ObjectType-Article-2
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Descrição: Summary Adrenal insufficiency is the clinical manifestation of deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from primary adrenal failure or secondary adrenal disease due to impairment of the hypothalamic–pituitary axis. Prompt diagnosis and management are essential. The clinical manifestations of primary adrenal insufficiency result from deficiency of all adrenocortical hormones, but they can also include signs of other concurrent autoimmune conditions. In secondary or tertiary adrenal insufficiency, the clinical picture results from glucocorticoid deficiency only, but manifestations of the primary pathological disorder can also be present. The diagnostic investigation, although well established, can be challenging, especially in patients with secondary or tertiary adrenal insufficiency. We summarise knowledge at this time on the epidemiology, causal mechanisms, pathophysiology, clinical manifestations, diagnosis, and management of this disorder.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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Adrenal insufficiency

Charmandari, Evangelia, Dr ; Nicolaides, Nicolas C, MD ; Chrousos, George P, Prof

Kidlington: Elsevier Ltd

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