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Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes

Nakamura, Akihiko ; Shikata, Kenichi ; Hiramatsu, Makoto ; Nakatou, Tatsuaki ; Kitamura, Takuya ; Wada, Jun ; Itoshima, Tatsuya ; Makino, Hirofumi

Diabetes care, 2005-12, Vol.28 (12), p.2890-2895 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes
Autor: Nakamura, Akihiko ; Shikata, Kenichi ; Hiramatsu, Makoto ; Nakatou, Tatsuaki ; Kitamura, Takuya ; Wada, Jun ; Itoshima, Tatsuya ; Makino, Hirofumi
Assuntos: Aged ; Asian people ; Associated diseases and complications ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Atherosclerosis - immunology ; Atherosclerosis - urine ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood Pressure ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular disease ; Cytokines ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - immunology ; Diabetes Mellitus, Type 2 - urine ; Diabetes. Impaired glucose tolerance ; Diabetic Angiopathies - blood ; Diabetic Angiopathies - immunology ; Diabetic Angiopathies - urine ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - immunology ; Diabetic Nephropathies - urine ; Diagnosis ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Health aspects ; Humans ; Interleukin-18 ; Interleukin-18 - blood ; Interleukin-18 - urine ; Interleukin-6 - blood ; Japan ; Male ; Medical sciences ; Middle Aged ; Patients ; Reference Values ; Regression Analysis ; Risk factors ; Type 2 diabetes
É parte de: Diabetes care, 2005-12, Vol.28 (12), p.2890-2895
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: OBJECTIVE:--Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS--Eighty-two Japanese patients with type 2 diabetes and 55 age- and sex-matched healthy control subjects were enrolled. Patients with renal dysfunction (creatinine clearance <1 ml/s) were excluded. We assessed clinical parameters and measured serum and urinary IL-18 levels, serum IL-6 levels, carotid intima-media thickness (IMT), and brachial-ankle pulse wave velocity (baPWV) in all patients. Further, we evaluated changes of urinary albumin excretion rate (AER) after 6 months in 76 diabetic patients. RESULTS:--Serum and urinary IL-18 levels were significantly elevated in patients with type 2 diabetes as compared with control subjects (serum IL-18 179 ± 62 vs. 121 ± 55 pg/ml, P < 0.001; urinary IL-18 97 ± 159 vs. 47 ± 54 pg/ml, P = 0.035). Univariate linear regression analysis showed significant positive correlations between serum IL-18 and AER (r [correlation coefficient] = 0.525, P < 0.001), HbA[subscript 1c] (r = 0.242, P = 0.029), high-sensitivity C-reactive protein (hs-CRP) (r = 0.240, P = 0.031), and urinary {szligbeta}-2 microglobulin (r = 0.235, P = 0.036). Serum IL-18 levels also correlated positively with carotid IMT (r = 0.225, P = 0.042) and baPWV (r = 0.232, P = 0.040). We also found a significant correlation between urinary IL-18 and AER (r = 0.309, P = 0.005). Multivariate linear regression analysis showed that AER (standard correlation coefficients [B] = 0.405, P < 0.001) and hs-CRP (B = 0.207, P = 0.033) were independently associated with serum IL-18 levels. AER was also independently associated with urinary IL-18 levels (B = 0.295, P = 0.005). Moreover, serum and urinary IL-18 levels correlated positively with AER after 6 months (r = 0.489, P < 0.001 and r = 0.320, P = 0.005) and changes in AER during the follow-up period (r = 0.268, P = 0.018 and r = 0.234, P = 0.042). CONCLUSIONS:--Serum levels of IL-18 might be a predictor of progression of diabetic nephropathy as well as cardiovascular diseases.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes

Nakamura, Akihiko ; Shikata, Kenichi ; Hiramatsu, Makoto ; Nakatou, Tatsuaki ; Kitamura, Takuya ; Wada, Jun ; Itoshima, Tatsuya ; Makino, Hirofumi

Alexandria, VA: American Diabetes Association

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