skip to main content
Idioma:

An immunotoxicity assessment of food flavouring ingredients

Gaworski, C.L. ; Vollmuth, T.A. ; Dozier, M.M. ; Heck, J.D. ; Dunn, L.T. ; Ratajczak, H.V. ; Thomas, P.T.

Food and chemical toxicology, 1994-05, Vol.32 (5), p.409-415 [Periódico revisado por pares]

Oxford: Elsevier Ltd

Texto completo disponível

Citações Citado por
  • Título:
    An immunotoxicity assessment of food flavouring ingredients
  • Autor: Gaworski, C.L. ; Vollmuth, T.A. ; Dozier, M.M. ; Heck, J.D. ; Dunn, L.T. ; Ratajczak, H.V. ; Thomas, P.T.
  • Assuntos: Animals ; Biological and medical sciences ; Erythrocytes - immunology ; Female ; Flavoring Agents - toxicity ; Food toxicology ; Hemolytic Plaque Technique ; Immunity - drug effects ; Immunity, Innate - drug effects ; Medical sciences ; Mice ; Sheep - immunology ; Toxicology
  • É parte de: Food and chemical toxicology, 1994-05, Vol.32 (5), p.409-415
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: A rapid screening protocol incorporating key elements of the US National Toxicology Program's immunotoxicity tier testing strategy was used to evaluate the effects of 35 commonly used food flavouring ingredients on humoral and cell-mediated immune responses. The test compounds were administered intragastrically on a daily basis for 5 days at three dose levels to female CD-1 or B6C3F 1 mice, 6–8 wk old. A host resistance assay ( Listeria monocytogenes bacterial challenge) was conducted to assess cell-mediated immunity. Humoral immunity was measured by the antibody plaque-forming cell (PFC) response to sheep erythrocytes. Body weights, lymphoid organ weights and spleen cellularity were also measured. Cyclophosphamide (80 mg/kg) served as an immunosuppressive positive control agent. The results indicated that the majority of the flavouring ingredients tested did not modulate the cell-mediated or humoral immune response. However, at very high dose levels, two of the materials tested, peppermint oil and citral dimethyl acetal, did increase mortality rate and reduce survival time in the host resistance assay. Neither of these materials significantly altered the PFC response. This rapid, economical screening battery for potential immunotoxicants proved to be a useful means of evaluating a large number of structurally diverse compounds and mixtures to prioritize them for more definitive testing.
  • Editor: Oxford: Elsevier Ltd
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  3 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.