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Predictors of freezing in Parkinson's disease: A survey of 6,620 patients

Macht, Michael ; Kaussner, Yvonne ; Möller, Jens Carsten ; Stiasny-Kolster, Karin ; Eggert, Karla Maria ; Krüger, Hans-Peter ; Ellgring, Heiner

Movement disorders, 2007-05, Vol.22 (7), p.953-956 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Predictors of freezing in Parkinson's disease: A survey of 6,620 patients
Autor: Macht, Michael ; Kaussner, Yvonne ; Möller, Jens Carsten ; Stiasny-Kolster, Karin ; Eggert, Karla Maria ; Krüger, Hans-Peter ; Ellgring, Heiner
Assuntos: Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antiparkinson Agents - therapeutic use ; Biological and medical sciences ; blockade ; Chi-Square Distribution ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Forecasting ; Freezing Reaction, Cataleptic - drug effects ; Freezing Reaction, Cataleptic - physiology ; Health Surveys ; Humans ; Male ; Medical sciences ; Middle Aged ; motor block ; motor vehicle crash ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Parkinson Disease - diet therapy ; Parkinson Disease - epidemiology ; Parkinson Disease - physiopathology ; protecting factor ; risk factor ; Severity of Illness Index ; Sex Factors
É parte de: Movement disorders, 2007-05, Vol.22 (7), p.953-956
Notas: istex:89B070ED9458B1A4BBB1E9108C9C5AAB3E2F9274
Kompetenznetz Parkinson Syndrom - No. BMBF 01GI0201
ArticleID:MDS21458
ark:/67375/WNG-TD2XL6CF-0
Deutsche Parkinson Vereinigung
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty‐seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and—as our data also showed—may cause traffic accidents in licensed patients. © 2007 Movement Disorder Society
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Predictors of freezing in Parkinson's disease: A survey of 6,620 patients

Macht, Michael ; Kaussner, Yvonne ; Möller, Jens Carsten ; Stiasny-Kolster, Karin ; Eggert, Karla Maria ; Krüger, Hans-Peter ; Ellgring, Heiner

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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