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The Role of Macrophage Migration Inhibitory Factor in Mouse Islet Transplantation

TOSO, Christian ; SERRE-BEINIER, Véronique ; SHAPIRO, A. M. James ; BERNEY, Thierry ; EMAMAULLEE, Juliet ; MERANI, Shaheed ; ARMANET, Mathieu ; WOJTUSCISZYN, Anne ; BOSCO, Domenico ; CALANDRA, Thierry ; ROGER, Thierry ; MOREL, Philippe

Transplantation, 2008-11, Vol.86 (10), p.1361-1369 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
The Role of Macrophage Migration Inhibitory Factor in Mouse Islet Transplantation
Autor: TOSO, Christian ; SERRE-BEINIER, Véronique ; SHAPIRO, A. M. James ; BERNEY, Thierry ; EMAMAULLEE, Juliet ; MERANI, Shaheed ; ARMANET, Mathieu ; WOJTUSCISZYN, Anne ; BOSCO, Domenico ; CALANDRA, Thierry ; ROGER, Thierry ; MOREL, Philippe
Assuntos: Animals ; Apoptosis ; Biological and medical sciences ; Blood Glucose ; Blood Glucose - metabolism ; Crosses, Genetic ; Diabetes Mellitus, Experimental ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - surgery ; Endocrinology and metabolism ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection ; Graft Rejection - genetics ; Graft Survival ; Graft Survival - genetics ; Human health and pathology ; Inflammation ; Intramolecular Oxidoreductases ; Intramolecular Oxidoreductases - deficiency ; Intramolecular Oxidoreductases - genetics ; Intramolecular Oxidoreductases - physiology ; Islets of Langerhans Transplantation ; Islets of Langerhans Transplantation - immunology ; Islets of Langerhans Transplantation - pathology ; Islets of Langerhans Transplantation - physiology ; Life Sciences ; Macrophage Activation ; Macrophage Migration-Inhibitory Factors ; Macrophage Migration-Inhibitory Factors - deficiency ; Macrophage Migration-Inhibitory Factors - genetics ; Macrophage Migration-Inhibitory Factors - physiology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Treatment Outcome
É parte de: Transplantation, 2008-11, Vol.86 (10), p.1361-1369
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by many tissues including pancreatic beta-cells. This study investigates the impact of MIF on islet transplantation using MIF knock-out (MIFko) mice. Early islet function, assessed with a syngeneic marginal islet mass transplant model, was enhanced when using MIFko islets (P<0.05 compared with wild-type [WT] controls). This result was supported by increased in vitro resistance of MIFko islets to apoptosis (terminal deoxynucleotide tranferase-mediated dUTP nick-end labeling assay), and by improved glucose metabolism (lower blood glucose levels, reduced glucose areas under curve and higher insulin release during intraperitoneal glucose challenges, and in vitro in the absence of MIF, P<0.01). The beneficial impact of MIFko islets was insufficient to delay allogeneic islet rejection. However, the rejection of WT islet allografts was marginally delayed in MIFko recipients by 6 days when compared with WT recipient (P<0.05). This effect is supported by the lower activity of MIF-deficient macrophages, assessed in vitro and in vivo by cotransplantation of islet/macrophages. Leukocyte infiltration of the graft and donor-specific lymphocyte activity (mixed lymphocyte reaction, interferon gamma ELISPOT) were similar in both groups. These data indicate that targeting MIF has the potential to improve early function after syngeneic islet transplantation, but has only a marginal impact on allogeneic rejection.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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The Role of Macrophage Migration Inhibitory Factor in Mouse Islet Transplantation

TOSO, Christian ; SERRE-BEINIER, Véronique ; SHAPIRO, A. M. James ; BERNEY, Thierry ; EMAMAULLEE, Juliet ; MERANI, Shaheed ; ARMANET, Mathieu ; WOJTUSCISZYN, Anne ; BOSCO, Domenico ; CALANDRA, Thierry ; ROGER, Thierry ; MOREL, Philippe

Hagerstown, MD: Lippincott Williams & Wilkins

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