skip to main content
Idioma:
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

Thota, Sreekanth ; Rodrigues, Daniel A ; Crans, Debbie C ; Barreiro, Eliezer J

Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.5805-5821 [Periódico revisado por pares]

United States: American Chemical Society

Texto completo disponível

Citações Citado por
  • Título:
    Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?
  • Autor: Thota, Sreekanth ; Rodrigues, Daniel A ; Crans, Debbie C ; Barreiro, Eliezer J
  • É parte de: Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.5805-5821
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Metal based therapeutics are a precious class of drugs in oncology research that include examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and therapeutics applications. Ruthenium compounds have shown selective bioactivity and the ability to overcome the resistance that platinum-based therapeutics face, making them effective oncotherapeutic competitors in rational drug invention approaches. The development of antineoplastic ruthenium therapeutics is of particular interest because ruthenium containing complexes NAMI-A, KP1019, and KP1339 entered clinical trials and DW1/2 is in preclinical levels. The very robust, conformationally rigid organometallic Ru­(II) compound DW1/2 is a protein kinase inhibitor and presents new Ru­(II) compound designs as anticancer agents. Over the recent years, numerous strategies have been used to encapsulate Ru­(II) derived compounds in a nanomaterial system, improving their targeting and delivery into neoplastic cells. A new photodynamic therapy based Ru­(II) therapeutic, TLD-1433, has also entered clinical trials. Ru­(II)-based compounds can also be photosensitizers for photodynamic therapy, which has proven to be an effective new, alternative, and noninvasive oncotherapy modality.
  • Editor: United States: American Chemical Society
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.