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Low dose of Concanavalin-A enhances innate immune response and prevents liver injury in mice infected with Candida albicans

Conchon-Costa, I ; Loyola, W ; Gaziri, L.C.J ; Custódio, L.A ; Felipe, I

FEMS immunology and medical microbiology, 2007-04, Vol.49 (3), p.330-336 [Periódico revisado por pares]

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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Título:
Low dose of Concanavalin-A enhances innate immune response and prevents liver injury in mice infected with Candida albicans
Autor: Conchon-Costa, I ; Loyola, W ; Gaziri, L.C.J ; Custódio, L.A ; Felipe, I
Assuntos: Alanine ; Alanine transaminase ; Alanine Transaminase - blood ; Animals ; Biological and medical sciences ; Candida albicans ; Candida albicans - growth & development ; Candida albicans - immunology ; Candidiasis - drug therapy ; Candidiasis - immunology ; Candidiasis - microbiology ; Candidiasis - pathology ; Colony Count, Microbial ; Concanavalin A - administration & dosage ; Concanavalin-A ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Histocytochemistry ; HIV ; Human immunodeficiency virus ; Immune clearance ; Immune response ; Immune system ; immunity ; Immunologic Factors - administration & dosage ; Infections ; Inflammation ; Inflammatory response ; Injury prevention ; innate immune response ; Innate immunity ; Liver ; Liver - immunology ; Liver - microbiology ; Liver - pathology ; Macrophages ; Macrophages, Peritoneal - immunology ; Mice ; Microbiology ; Miscellaneous ; Mushrooms ; Mycology ; Peritoneum ; Phagocytosis ; Pretreatment ; Subgroups ; Survival Analysis ; TNF-α ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α
É parte de: FEMS immunology and medical microbiology, 2007-04, Vol.49 (3), p.330-336
Notas: http://dx.doi.org/10.1111/j.1574-695X.2006.00201.x
Editor: Artur Ulmer
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: The mechanisms through which Candida albicans is recognized by immune cells and how it triggers host defence are not completely understood. In this study, we evaluated the effect of Concanavalin-A on the clearance of C. albicans by infected mice and their production of proinflammatory cytokine tumor necrosis factor-α (TNF-α). Subgroups of 5 animals were pretreated with Con-A (250 μg mL⁻¹ PBS) and after 96 h were infected intraperitoneally with 10⁷ cells of C. albicans CR15 (an isolate from a HIV+ person); 30 min, 2, 6, 24 or 72 h after infection the mice were sacrificed. Phagocytosis of C. albicans by peritoneal macrophages increased 30 min after infection in mice pretreated with Con-A. The liver presented the greatest number of CFUs, and this number was reduced by pretreatment with Con-A. Control animals infected with C. albicans presented a significant increase in plasmatic alanine aminotransferase, which was not observed in mice treated with Con-A. Two hours after infection the production of TNF-α in the liver of mice pretreated with Con-A was significantly increased. These results suggest that a single dose of Con-A caused a beneficial modulating action of the inflammatory response during infection with C. albicans.
Editor: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Idioma: Inglês

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Low dose of Concanavalin-A enhances innate immune response and prevents liver injury in mice infected with Candida albicans

Conchon-Costa, I ; Loyola, W ; Gaziri, L.C.J ; Custódio, L.A ; Felipe, I

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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