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Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels

Lourdes Rehder de Andrade Vaz de Lima Euclides A. de Castilho; Helena Keico Sato; Eder Gatti Fernandes; Ana Paula Sayuri Sato; Lúcia C Pawloski; Maria Lúcia Tondella; Cyro A. de Brito; Expedito José de Albuquerque Luna; Telma Regina M.P Carvalhanas; The Maternal Pertussis Vaccine Working Group

Vaccine Amsterdam v.37, n.36, p.5474-5480, 2019

Amsterdam 2019

Localização: FM - Fac. Medicina    (OPI 34080 2019 ) e outros locais(Acessar)

  • Título:
    Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels
  • Autor: Lourdes Rehder de Andrade Vaz de Lima
  • Euclides A. de Castilho; Helena Keico Sato; Eder Gatti Fernandes; Ana Paula Sayuri Sato; Lúcia C Pawloski; Maria Lúcia Tondella; Cyro A. de Brito; Expedito José de Albuquerque Luna; Telma Regina M.P Carvalhanas; The Maternal Pertussis Vaccine Working Group
  • Assuntos: SAÚDE MATERNO-INFANTIL; COQUELUCHE; VACINAÇÃO; ANTICORPOS
  • É parte de: Vaccine Amsterdam v.37, n.36, p.5474-5480, 2019
  • Notas: Disponível em: . Acesso em: 04 dez. 2019
  • Descrição: Background:Pertussis remains an important global public health concern, despite the presence of exten-sive immunization programs. Incidence and severity of pertussis are typically higher in neonates andyoung infants. As a strategy to protect these young infants, maternal vaccination with Tdap (tetanus tox-oid, reduced diphtheria toxoid, and acellular pertussis) has been recommended in Brazil. The objective ofthis study was to evaluate the effects of Tdap vaccination during pregnancy on the anti-pertussis toxin(PT) IgG response in mothers and their infants at birth.Material and methods:Maternal and cord blood samples were collected from vaccinated (n = 243) andunvaccinated (n = 75) pregnant women, at the time of delivery, from July 2015 to August 2016 in SãoPaulo, Brazil. Anti-PT IgG antibodies were quantified by Enzyme-Linked Immunosorbent Assay (ELISA)and geometric mean concentrations (GMC) were calculated. Relationship between timing of vaccinationand antibody concentrations were evaluated.Results:Maternal and cord blood GMCs among the vaccinated group were 5.4 and 5.6 fold higher [66.5International Units (IU)/mL and 89.8 IU/mL] compared to the unvaccinated group (12.4 IU/mL and16.1 IU/mL), respectively (p < 0.001). Higher anti-PT IgG GMCs were observed when vaccination occurred 60 days before delivery compared to <60 days, suggesting that vaccination early in the third trimestermay be more effective than later in pregnancy.Conclusion:Tdap maternal vaccination results in significantly higher anti-PT IgG in newborn infants andsupports the current recommendation of the Brazilian Immunization Program
  • Editor: Amsterdam
  • Data de criação/publicação: 2019
  • Formato: p.5474-5480.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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