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The role of dietary fatty acid intake in inflammatory gene expression: a critical review

Rocha, Daniela Mayumi ; Bressan, Josefina ; Hermsdorff, Helen Hermana

São Paulo medical journal, 2017-03, Vol.135 (2), p.157-168 [Periódico revisado por pares]

Brazil: Associação Paulista de Medicina - APM

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  • Título:
    The role of dietary fatty acid intake in inflammatory gene expression: a critical review
  • Autor: Rocha, Daniela Mayumi ; Bressan, Josefina ; Hermsdorff, Helen Hermana
  • Assuntos: Diet, High-Fat ; Dietary Fats - administration & dosage ; Energy Intake ; Expressão gênica ; Fatty Acids - administration & dosage ; Female ; Gene Expression ; Gorduras insaturadas na dieta ; Gorduras na dieta ; Humans ; Inflamação ; Inflammation - diet therapy ; Leukocytes, Mononuclear ; Male ; MEDICINE, GENERAL & INTERNAL ; Postprandial Period ; Ácidos graxos
  • É parte de: São Paulo medical journal, 2017-03, Vol.135 (2), p.157-168
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Diet is an important modifiable factor involved in obesity-induced inflammation. We reviewed clinical trials that assessed the effect of consumption of different fatty acids on the expression of inflammation-related genes, such as cytokines, adipokines, chemokines and transcription factors. Narrative review study conducted at a research center. This was a review on the effect of fat intake on inflammatory gene expression in humans. Consumption of saturated fatty acids (SFAs) was related to postprandial upregulation of genes associated with pro-inflammatory pathways in peripheral blood mononuclear cells (PBMCs), in comparison with monounsaturated fatty acid (MUFA) or polyunsaturated fatty acid (PUFA) intake. In addition, acute intake of a high-SFA meal also induced a postprandial pro-inflammatory response for several inflammatory genes in subcutaneous adipose tissue. Both high-MUFA and high-PUFA diets showed anti-inflammatory profiles, or at least a less pronounced pro-inflammatory response than did SFA consumption. However, the results concerning the best substitute for SFAs were divergent because of the large variability in doses of MUFA (20% to 72% of energy intake) and n3 PUFA (0.4 g to 23.7% of energy intake) used in interventions. The lipid profile of the diet can modulate the genes relating to postprandial and long-term inflammation in PBMCs and adipose tissue. Identifying the optimal fat profile for inflammatory control may be a promising approach for treating chronic diseases such as obesity.
  • Editor: Brazil: Associação Paulista de Medicina - APM
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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