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Establishment of A Mixed Chimeric Mouse Model of Allogeneic Bone Marrow Transplantation and Its Influencing Factors

He, Qiao-Mei ; Yu, Fang-Fang ; Sun, Xi ; Ding, Xiao-Dan ; Yuan, Xiu-Jie ; Zhang, Yan ; Song, Xian-Min

Zhongguo shi yan xue ye xue za zhi, 2021-04, Vol.29 (2), p.603-609

China

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  • Título:
    Establishment of A Mixed Chimeric Mouse Model of Allogeneic Bone Marrow Transplantation and Its Influencing Factors
  • Autor: He, Qiao-Mei ; Yu, Fang-Fang ; Sun, Xi ; Ding, Xiao-Dan ; Yuan, Xiu-Jie ; Zhang, Yan ; Song, Xian-Min
  • Assuntos: Animals ; Bone Marrow Transplantation ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Mice ; Retrospective Studies ; Transplantation Chimera ; Transplantation Conditioning ; Transplantation, Homologous
  • É parte de: Zhongguo shi yan xue ye xue za zhi, 2021-04, Vol.29 (2), p.603-609
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: To establish a mouse mixed chimerism (MC) model of nonmyeloablative allogeneic bone marrow transplantation(allo-BMT) and explore its affecting factors. The MC model was established by nonmyeloablative allo-BMT followed by high-dose post-transplant cyclophosphamide (PTCY). 123 mice in the experiments was retrospectively analyzed, and the factors related with the chimerism were explored with the univariate and multivariate logistic regression analysis. A multivariate linear regression was performed by R project to obtain a mathematical model for predicting the chimeric level with relevant affecting factors. The model presented mixed chimerism on day 14 after transplantation, and was characterized by a donor lymphocyte infusion (DLI) which significantly promoted donor engraftment on day 15, but transfplantation of PBS in control group was failed. Among 123 mice, 47 (38.21%) mice were MC, while 76 (61.79%) mice were non-MC in 123 mice, respectively; univariate analysis showed that the baseline body weight of mice
  • Editor: China
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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