Self
-
organization
principles of intracellular pattern formation
ABCD PBi
Self
-
organization
principles of intracellular pattern formation
Autor:
Halatek, J.
;
Brauns, F.
;
Frey, E.
Assuntos:
Animals
;
Caenorhabditis elegans - genetics
;
Caenorhabditis elegans Proteins - genetics
;
cdc42 GTP-Binding Protein, Saccharomyces cerevisiae - genetics
;
Cdc42 protein
;
Cellpolarity
;
Diffusion
;
E coli
;
Escherichia coli - genetics
;
Escherichia coli Proteins - genetics
;
Eukaryotes
;
Evolution, Molecular
;
Fungi
;
Intracellular
;
Intracellular Patterns
;
Mathematical models
;
Min protein
;
Models, Genetic
;
Ntpases
;
Pattern Formation
;
Patterning
;
Prokaryotes
;
Protein transport
;
Proteins
;
Reaction–diffusion
;
Review
;
Saccharomyces cerevisiae
;
Saccharomyces cerevisiae - genetics
;
Self
-
Organization
;
Substrate inhibition
;
Transport
É parte de:
Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2018-05, Vol.373 (1747), p.20170107-20170107
Notas:
Theme issue ‘Self-organization in cell biology’ compiled and edited by Timo Betz and Roland Wedlich-Söldner
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
One contribution of 15 to a theme issue ‘Self-organization in cell biology’.
Descrição:
Dynamic patterning of specific proteins is essential for the spatio-temporal regulation of many important intracellular processes in prokaryotes, eukaryotes and multicellular organisms. The emergence of patterns generated by interactions of diffusing proteins is a paradigmatic example for
self
-
organization
. In this article, we review quantitative models for intracellular Min protein patterns in Escherichia coli, Cdc42 polarization in Saccharomyces cerevisiae and the bipolar PAR protein patterns found in Caenorhabditis elegans. By analysing the molecular processes driving these systems we derive a theoretical perspective on general principles underlying
self
-organized pattern formation. We argue that intracellular pattern formation is not captured by concepts such as ‘activators’, ‘inhibitors’ or ‘substrate depletion’. Instead, intracellular pattern formation is based on the redistribution of proteins by cytosolic diffusion, and the cycling of proteins between distinct conformational states. Therefore, mass-conserving reaction–diffusion equations provide the most appropriate framework to study intracellular pattern formation. We conclude that directed transport, e.g. cytosolic diffusion along an actively maintained cytosolic gradient, is the key process underlying pattern formation. Thus the basic principle of self-organization is the establishment and maintenance of directed transport by intracellular protein dynamics. This article is part of the theme issue ‘Self-organization in cell biology’.
Editor:
England: The Royal Society
Idioma:
Inglês