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Cytotoxicity of capsaicin and its analogs in vitro

Santos, V A M ; Bressiani, P A ; Zanotto, A W ; Almeida, I V ; Berti, A P ; Lunkes, A M ; Vicentini, V E P ; Düsman, E

Brazilian journal of biology, 2023, Vol.83, p.e268941-6 [Periódico revisado por pares]

Brazil: Instituto Internacional de Ecologia

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Título:
Cytotoxicity of capsaicin and its analogs in vitro
Autor: Santos, V A M ; Bressiani, P A ; Zanotto, A W ; Almeida, I V ; Berti, A P ; Lunkes, A M ; Vicentini, V E P ; Düsman, E
Assuntos: Analogs ; Animals ; Biological activity ; BIOLOGY ; Capsaicin ; Capsaicin - chemistry ; Capsaicin - pharmacology ; Capsicum ; Cell cycle ; Cell growth ; Cytotoxicity ; Diabetic neuropathy ; Hepatoma ; Hydroxyl radicals ; Metabolism ; Molecular chains ; Natural products ; Pharmacokinetics ; Plants ; Pungent principles ; Rats ; Rattus norvegicus ; Toxicity testing ; Variance analysis
É parte de: Brazilian journal of biology, 2023, Vol.83, p.e268941-6
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Capsaicin (CAP) is the main compound responsible for the spicy flavor of Capsicum plants. However, its application can be inhibited due to its pungency and toxicity. This study aimed to evaluate and compare the cytotoxic effect of CAP and its analogs N-benzylbutanamide (AN1), N-(3-methoxybenzyl) butanamide (AN2), N-(4-hydroxy-3-methoxybenzyl) butanamide (AN3), N-(4-hydroxy-3-methoxybenzyl) hexanamide (AN4) and N-(4-hydroxy-3-methoxybenzyl) tetradecanamide (AN5) on the hepatoma cells of Rattus norvegicus using the MTT test. The results showed cytotoxicity of CAP at concentrations of 100, 150, 175, and 200 μM (24 hours), AN1 at 150 and 175 μM (48 hours), AN2 at 50 μM (24 hours) and 10, 25, 50, and 75 μM (48 hours), AN4 at 175 μM (24 hours), and AN5 at 50 μM (48 hours). Removing the hydroxyl radical from the vanillyl group of capsaicin, together with reducing the acyl chain to 3 carbons, which is the case of AN2, resulted in the best biological activity. Increasing the carbon chain in the acyl group of the capsaicin molecule, which is the case of AN5, also showed evident cytotoxic effects. The present study proves that the chemical modifications of capsaicin changed its biological activity.
Editor: Brazil: Instituto Internacional de Ecologia
Idioma: Inglês;Português

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Cytotoxicity of capsaicin and its analogs in vitro

Santos, V A M ; Bressiani, P A ; Zanotto, A W ; Almeida, I V ; Berti, A P ; Lunkes, A M ; Vicentini, V E P ; Düsman, E

Brazil: Instituto Internacional de Ecologia

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