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Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

Nguyen, Frédérique ; Peña, Laura ; Ibisch, Catherine ; Loussouarn, Delphine ; Gama, Adelina ; Rieder, Natascha ; Belousov, Anton ; Campone, Mario ; Abadie, Jérôme

Breast cancer research and treatment, 2018-02, Vol.167 (3), p.635-648 [Periódico revisado por pares]

New York: Springer US

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Título:
Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors
Autor: Nguyen, Frédérique ; Peña, Laura ; Ibisch, Catherine ; Loussouarn, Delphine ; Gama, Adelina ; Rieder, Natascha ; Belousov, Anton ; Campone, Mario ; Abadie, Jérôme
Assuntos: Animal models ; Animals ; Breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Cancer ; Cancer research ; Clinical trials ; Disease Models, Animal ; Dogs ; Epidermal growth factor ; Epidermal growth factor receptors ; Epidermal growth factors ; Estrogen ; Estrogens ; Female ; Humans ; Invasiveness ; Life Sciences ; Mammary gland ; Mammary Neoplasms, Animal - genetics ; Mammary Neoplasms, Animal - pathology ; Mammary Neoplasms, Animal - surgery ; Mastectomy ; Medical prognosis ; Medicine ; Medicine & Public Health ; Multivariate Analysis ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; Oncology ; Preclinical Study ; Progesterone ; Prognosis ; Receptor, ErbB-2 - genetics ; Receptors, Estrogen - genetics ; Receptors, Progesterone - genetics ; Survival
É parte de: Breast cancer research and treatment, 2018-02, Vol.167 (3), p.635-648
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Purpose Dogs have been proposed as spontaneous animal models of human breast cancer, based on clinicopathologic similarities between canine and human mammary carcinomas. We hypothesized that a better knowledge of the natural history and prognostic factors of canine invasive mammary carcinomas would favor the design of preclinical trials using dogs as models of breast cancer. Methods The 2-year outcome of 350 female dogs with spontaneous invasive mammary carcinoma was studied. The investigated prognostic factors included age at diagnosis, pathologic tumor size, pathologic nodal stage, lymphovascular invasion, histological grade, and expression of Estrogen Receptor alpha (ERα), Progesterone Receptor, Ki-67, Human Epidermal Growth Factor Receptor 2, basal cytokeratins 5/6, and Epidermal Growth Factor Receptor. Multivariate survival analyses were performed using the Cox proportional hazards model. Results The overall survival after mastectomy was 11 months. Within 1 year post mastectomy, 41.5% of dogs (145/350) died from their mammary carcinoma. By multivariate analysis, the significant prognostic factors for overall survival included a pathologic tumor size larger than 20 mm [HR 1.47 (95% confidence interval 1.15–1.89)], a positive nodal stage [pN+, HR 1.89 (1.43–2.48)], a histological grade III [HR 1.32 (1.02–1.69)], ERα negativity [HR 1.39 (1.01–1.89)], a high Ki-67 proliferation index [HR 1.32 (1.04–1.67)], and EGFR absence [HR 1.33 (1.04–1.69)]. Conclusion The short natural history of spontaneous canine invasive mammary carcinomas and high rate of cancer-related death allow for rapid termination of preclinical investigations. The prognostic factors of invasive mammary carcinomas are remarkably similar in dogs and humans, highlighting the similarities in cancer biology between both species.
Editor: New York: Springer US
Idioma: Inglês

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Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

Nguyen, Frédérique ; Peña, Laura ; Ibisch, Catherine ; Loussouarn, Delphine ; Gama, Adelina ; Rieder, Natascha ; Belousov, Anton ; Campone, Mario ; Abadie, Jérôme

New York: Springer US

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