Idioma:

The effects of periodontitis associated microbiota on the development of oral squamous cell carcinoma

Hu, Xiaoyu ; Shen, Xin ; Tian, Jiangxue

Biochemical and biophysical research communications, 2021-10, Vol.576, p.80-85 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
The effects of periodontitis associated microbiota on the development of oral squamous cell carcinoma
Autor: Hu, Xiaoyu ; Shen, Xin ; Tian, Jiangxue
Assuntos: Bacteroidaceae Infections - complications ; Bacteroidaceae Infections - microbiology ; Bacteroidaceae Infections - pathology ; Cell Line, Tumor ; Cell Movement - physiology ; Corynebacterium - genetics ; Corynebacterium - isolation & purification ; Fusobacterium Infections - complications ; Fusobacterium Infections - microbiology ; Fusobacterium Infections - pathology ; Fusobacterium nucleatum - genetics ; Fusobacterium nucleatum - isolation & purification ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - microbiology ; Head and Neck Neoplasms - pathology ; Humans ; Invasion ; Microbiota ; Migration ; Neisseria sicca - genetics ; Neisseria sicca - isolation & purification ; Neisseriaceae Infections - complications ; Neisseriaceae Infections - microbiology ; Neisseriaceae Infections - pathology ; Oral squamous cell carcinoma ; Periodontitis ; Periodontitis - microbiology ; Periodontitis associated microbiota ; Porphyromonas gingivalis - genetics ; Porphyromonas gingivalis - isolation & purification ; Proliferation ; Squamous Cell Carcinoma of Head and Neck - metabolism ; Squamous Cell Carcinoma of Head and Neck - microbiology ; Squamous Cell Carcinoma of Head and Neck - pathology
É parte de: Biochemical and biophysical research communications, 2021-10, Vol.576, p.80-85
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: Epidemiological data have shown that periodontal bacterial infection, periodontitis, and oral squamous cell carcinoma have close relationship on the disease progress and risk. However, the specific role of periodontal microbes and their mechanism in the development of oral squamous cell carcinoma is not yet clear. In our previous work, metagenomic Illumina Mi-seq analysis was used to identify tstructure and abundance of periodontital microbiome. Accoding to the results, we used Porphyromonas.spp. and Fusobacterium.spp. as the periodontitis positive microbiota; Neisseria.spp and Corynebacterium.spp as periodontitis negative microbiota (their average relative abundance were >5%). These representative strains of the above genus were used to infect OSCC cells to explore their effect on tumor cell biology behavior, and detect the expression level of the gene in related to inflammation, migration, invasion and cell cycle. We find that periodontitis positive correlated microbiota had a promoting effect on the development of oral squamous cell carcinoma in vitro by regulating mRNA and protein expression of IL-6, IL-8, MMP-9 and Cyclin-D1. Periodontitis negative correlated microbiota had suppression effect on the development of oral squamous cell carcinoma in vitro analysis. ∙Focusing on the functional annotation of metagenomic sequencing results and verifying their functions is expected to lead to an in-depth understanding of the function of the microbial community and insights into the mechanisms of microbiome-induced cancer.∙The results indicated that the reason healthy people have a lower incidence of OSCC than those with periodontitis may be related to the negative bacteria associated with periodontitis.∙Our research further suggests that monitoring changes in the oral microbial community structure will be helpful in the assessment of the prognosis and efficacy of OSCC. Detection of changes in the oral microbial community may also be a potential method for early auxiliary screening of OSCC.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

The effects of periodontitis associated microbiota on the development of oral squamous cell carcinoma

Hu, Xiaoyu ; Shen, Xin ; Tian, Jiangxue

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.