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Immunocytochemical detection of GABAergic nerve cells in the human temporal cortex using a direct γ-aminobutyric acid antiserum

Schiffmann, S. ; Campistron, G. ; Tugendhaft, P. ; Brotchi, J. ; Flament-Durand, J. ; Geffard, M. ; Vanderhaeghen, J.-J.

Brain research, 1988-03, Vol.442 (2), p.270-278 [Periódico revisado por pares]

London: Elsevier B.V

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Título:
Immunocytochemical detection of GABAergic nerve cells in the human temporal cortex using a direct γ-aminobutyric acid antiserum
Autor: Schiffmann, S. ; Campistron, G. ; Tugendhaft, P. ; Brotchi, J. ; Flament-Durand, J. ; Geffard, M. ; Vanderhaeghen, J.-J.
Assuntos: Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebral biopsy ; Fundamental and applied biological sciences. Psychology ; GABAergic nerve cell ; gamma-Aminobutyric Acid - analysis ; gamma-Aminobutyric Acid - immunology ; Glutaraldehyde ; Human temporal cortex ; Humans ; Immune Sera ; Immunocytochemistry ; Immunoenzyme Techniques ; Neurons - cytology ; Temporal Lobe - cytology ; Temporal Lobe - pathology ; Vertebrates: nervous system and sense organs ; γ-Aminobutyrate
É parte de: Brain research, 1988-03, Vol.442 (2), p.270-278
Notas: ObjectType-Article-2
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Descrição: Recently, an immunocytochemical method using glutaraldehyde fixation and an antiserum developed against a GABA-glutaraldehyde-protein conjugate has permitted direct visualization of GABAergic structures in the brains of perfused animals. This paper reports a successful use of this technique on human temporal cortex fixed by immersion. The cerebral tissue was obtained from patients operated for focal epilepsy. GABA-positive somata, fibres and terminals are observed in all layers of the temporal cortex. Terminals are particularly abundant in the superficial portion of layer I and in layers II, III and IV. Dense plexuses of fibres are located in layers II, III, IV and VI and in the underlying white matter. Somata are found in all cortical layers and in the underlying white matter; they are round, oval, fusiform or triangular and exhibit a multipolar, bitufted or bipolar dendric pattern. This technique for the visualization of GABAergic structures in the human brain may allow a better understanding of the pathogeny of epilepsy in which the GABAergic transmission has been implicated.
Editor: London: Elsevier B.V
Idioma: Inglês

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Immunocytochemical detection of GABAergic nerve cells in the human temporal cortex using a direct γ-aminobutyric acid antiserum

Schiffmann, S. ; Campistron, G. ; Tugendhaft, P. ; Brotchi, J. ; Flament-Durand, J. ; Geffard, M. ; Vanderhaeghen, J.-J.

London: Elsevier B.V

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