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Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson’s disease

Yue, X ; Hariri, D.J ; Caballero, B ; Zhang, S ; Bartlett, M.J ; Kaut, O ; Mount, D.W ; Wüllner, U ; Sherman, S.J ; Falk, T

Neuroscience, 2014-01, Vol.258, p.385-400 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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Título:
Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson’s disease
Autor: Yue, X ; Hariri, D.J ; Caballero, B ; Zhang, S ; Bartlett, M.J ; Kaut, O ; Mount, D.W ; Wüllner, U ; Sherman, S.J ; Falk, T
Assuntos: Aged ; Aged, 80 and over ; Animals ; Biological and medical sciences ; Cell Line, Tumor ; Corpus Striatum - drug effects ; Corpus Striatum - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Models, Animal ; FATP1 ; FATP4 ; Glial Cell Line-Derived Neurotrophic Factor - pharmacology ; human substantia nigra pars compacta ; Humans ; Male ; Medical sciences ; mitochondria ; Motor Activity - drug effects ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Neurons - drug effects ; Neurons - physiology ; neuroprotective factors ; Nootropic Agents - pharmacology ; Oxidopamine ; Parkinson Disease - drug therapy ; Parkinson Disease - physiopathology ; Rats ; Rats, Sprague-Dawley ; rodent 6-OHDA model ; Substantia Nigra - drug effects ; Substantia Nigra - physiopathology ; Vascular Endothelial Growth Factor B - pharmacology
É parte de: Neuroscience, 2014-01, Vol.258, p.385-400
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Highlights • Neuroprotective effects of VEGF-B in rat 6-OHDA model are comparable to GDNF. • VEGF-B is not neurorestorative in rat 6-OHDA model, while GDNF is. • VEGF-B expression has a strong correlation with mitochondrial genes in rat midbrain. • VEGF-B restored reduced levels of FATP1+4 and Phospho-Akt post-rotenone in SH-SY5Y. • VEGF-B is expressed in the human substantia nigra pars compacta of PD patients.
Editor: Amsterdam: Elsevier Ltd
Idioma: Inglês

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Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson’s disease

Yue, X ; Hariri, D.J ; Caballero, B ; Zhang, S ; Bartlett, M.J ; Kaut, O ; Mount, D.W ; Wüllner, U ; Sherman, S.J ; Falk, T

Amsterdam: Elsevier Ltd

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