skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Changing Characteristics of Staphylococcus aureus Bacteremia: Results From a 21-Year, Prospective, Longitudinal Study

Souli, Maria ; Ruffin, Felicia ; Choi, Seong-Ho ; Park, Lawrence P ; Gao, Shengli ; Lent, Nicholas Christopoulos ; Sharma-Kuinkel, Batu K ; Thaden, Joshua T ; Maskarinec, Stacey A ; Wanda, Lisa ; Hill-Rorie, Jonathan ; Warren, Bobby ; Hansen, Brenda ; Fowler, Vance G

Clinical infectious diseases, 2019-11, Vol.69 (11), p.1868-1877 [Periódico revisado por pares]

US: Oxford University Press

Texto completo disponível

Citações Citado por
  • Título:
    Changing Characteristics of Staphylococcus aureus Bacteremia: Results From a 21-Year, Prospective, Longitudinal Study
  • Autor: Souli, Maria ; Ruffin, Felicia ; Choi, Seong-Ho ; Park, Lawrence P ; Gao, Shengli ; Lent, Nicholas Christopoulos ; Sharma-Kuinkel, Batu K ; Thaden, Joshua T ; Maskarinec, Stacey A ; Wanda, Lisa ; Hill-Rorie, Jonathan ; Warren, Bobby ; Hansen, Brenda ; Fowler, Vance G
  • Assuntos: and Commentaries ; Editor's Choice
  • É parte de: Clinical infectious diseases, 2019-11, Vol.69 (11), p.1868-1877
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Abstract Background We conducted a longitudinal study to evaluate changes in the clinical presentation and epidemiology of Staphylococcus aureus bacteremia (SAB) in an academic, US medical center. Methods Consecutive patients with monomicrobial SAB were enrolled from January 1995 to December 2015. Each person’s initial bloodstream S. aureus isolate was genotyped using spa typing. Clonal complexes (CCs) were assigned using Ridom StaphType software. Changes over time in both the patient and bacterial characteristics were estimated with linear regression. Associations between genotypes or clinical characteristics and complications were estimated using multivariable regression models. Results Among the 2348 eligible participants, 54.2% had an implantable, foreign body of some type. This proportion increased significantly during the 21-year study period, by 0.96% annually (P = .002), as did comorbid conditions and acquisition outside of the hospital. Rates of any metastatic complication also significantly increased, by 0.94% annually (P = .019). Among the corresponding bloodstream S. aureus isolates, spa-CC012 (multi-locus sequence type [MLST] CC30), -CC004 (MLST CC45), -CC189 (MLST CC1), and -CC084 (MLST CC15) all significantly declined during the study period, while spa-CC008 (MLST CC8) significantly increased. Patients with SAB due to spa-CC008 were significantly more likely to develop metastatic complications in general, and abscesses, septic emboli, and persistent bacteremia in particular. After adjusting for demographic, racial, and clinical variables, the USA300 variant of spa-CC008 was independently associated with metastatic complications (odds ratio 1.42; 95% confidence interval 1.02–1.99). Conclusions Systematic approaches for monitoring complications of SAB and genotyping the corresponding bloodstream isolates will help identify the emergence of hypervirulent clones and likely improve clinical management of this syndrome. During 21 years of continuous enrollment in this prospective, observational cohort study of 2348 patients, bacterial genotypes, patient characteristics, and metastatic complication rates changed significantly. The emergence of the USA300 genotype was independently associated with an increase in metastatic complications.
  • Editor: US: Oxford University Press
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.