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Micromolar copper modifies electrical properties and spontaneous discharges of nodose ganglion neurons in vitro

Ortiz, Fernando C. ; Vergara, Cecilia ; Alcayaga, Julio

Biometals, 2014-02, Vol.27 (1), p.45-52 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Micromolar copper modifies electrical properties and spontaneous discharges of nodose ganglion neurons in vitro
Autor: Ortiz, Fernando C. ; Vergara, Cecilia ; Alcayaga, Julio
Assuntos: Animals ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Membrane Permeability ; Central nervous system ; Copper ; Copper - metabolism ; Descriptions ; Electric properties ; ELECTRICAL PROPERTIES ; Electrophysiological Phenomena ; In vitro testing ; Life Sciences ; Male ; Medicine/Public Health ; Membrane Potentials ; MEMBRANES ; Microbiology ; Neurology ; Neurons ; Neurons - metabolism ; Nodose Ganglion - cytology ; Peripheral Nerves - cytology ; Peripheral Nerves - metabolism ; Pharmacology/Toxicology ; Plant Physiology ; PROPERTIES ; Rabbits ; Recording ; Studies
É parte de: Biometals, 2014-02, Vol.27 (1), p.45-52
Notas: ObjectType-Article-1
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Descrição: Copper plays a key role in aerobic cell physiology mainly related to mitochondrial metabolism. This element is also present at higher than basal levels in some central nuclei and indeed, current evidence support copper’s role as a neuromodulator in the central nervous system. More recent data indicate that copper may also affect peripheral neuronal activity, but so far, there are not detailed descriptions of what peripheral neuronal characteristics are targeted by copper. Here, we studied the effect of physiological concentration of CuCl 2 (μM range) on the activity of peripheral neurons using a preparation of nodose ganglion in vitro. By mean of conventional intracellular recordings passive and active electrical membrane properties were studied. Extracellular copper modified (in a redox-independent manner) the resting membrane potential and the input resistance of the nodose ganglion neurons, increasing the excitability in most of the tested neurons. These results suggest that Cu 2+ modulates the activity of nodose ganglion neurons and support nodose ganglion in vitro preparation as a simple model to study the subcellular mechanisms involved in the Cu 2+ effects on neuron electrical properties.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês;Holandês

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Micromolar copper modifies electrical properties and spontaneous discharges of nodose ganglion neurons in vitro

Ortiz, Fernando C. ; Vergara, Cecilia ; Alcayaga, Julio

Dordrecht: Springer Netherlands

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