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Relevant Animal Models in Dermatophyte Research

Cambier, Ludivine ; Heinen, Marie-Pierre ; Mignon, Bernard

Mycopathologia (1975), 2017-02, Vol.182 (1-2), p.229-240 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Relevant Animal Models in Dermatophyte Research
Autor: Cambier, Ludivine ; Heinen, Marie-Pierre ; Mignon, Bernard
Assuntos: Animal experimentation ; Animals ; Antifungal Agents - isolation & purification ; Antifungal Agents - therapeutic use ; Arthrodermataceae - immunology ; Biomedical and Life Sciences ; Comparative analysis ; Dermatomycoses - drug therapy ; Dermatomycoses - immunology ; Dermatomycoses - microbiology ; Dermatomycoses - pathology ; Disease Models, Animal ; Eukaryotic Microbiology ; Fungi ; Guinea Pigs ; Health aspects ; Host-Pathogen Interactions ; Immune response ; Infection ; Infections ; Keratin ; Laboratory animals ; Life Sciences ; Medical Microbiology ; Medical research ; Mice ; Microbial Ecology ; Microbiology ; Mycoses ; Médecine vétérinaire & santé animale ; Plant Sciences ; Sciences du vivant ; Skin ; Vaccines ; Veterinary medicine ; Veterinary medicine & animal health
É parte de: Mycopathologia (1975), 2017-02, Vol.182 (1-2), p.229-240
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
scopus-id:2-s2.0-84991109284
Descrição: Dermatophytoses are common superficial fungal infections affecting both humans and animals. They are provoked by filamentous fungi called dermatophytes specialized in the degradation of keratinized structures, which allows them to induce skin, hair and nail infections. Despite their high incidence, little investigation has been performed for the understanding of these infections compared to fungal opportunistic infections and most of the studies were based on in vitro experiments. The development of animal models for dermatophyte research is required to evaluate new treatments against dermatophytoses or to increase knowledge about fungal pathogenicity factors or host immune response mechanisms. The guinea pig has been the most often used animal model to evaluate efficacy of antifungal compounds against dermatophytes, while mouse models were preferred to study the immune response generated during the disease. Here, we review the relevant animal models that were developed for dermatophyte research and we discuss the advantages and disadvantages of the selected species, especially guinea pig and mouse.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

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Relevant Animal Models in Dermatophyte Research

Cambier, Ludivine ; Heinen, Marie-Pierre ; Mignon, Bernard

Dordrecht: Springer Netherlands

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