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Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire

Gilbert-Diamond, Diane ; Emond, Jennifer A ; Baker, Emily R ; Korrick, Susan A ; Karagas, Margaret R

Environmental health perspectives, 2016-08, Vol.124 (8), p.1299-1307 [Periódico revisado por pares]

United States: National Institute of Environmental Health Sciences

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  • Título:
    Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire
  • Autor: Gilbert-Diamond, Diane ; Emond, Jennifer A ; Baker, Emily R ; Korrick, Susan A ; Karagas, Margaret R
  • Assuntos: Analysis ; Arsenic ; Arsenic - metabolism ; Cell division ; Children's Health ; Environmental Pollutants - metabolism ; Female ; Fetal development ; Fetus ; Groundwater ; Growth ; Health aspects ; Health risk assessment ; Humans ; Infant, Newborn ; Infants (Newborn) ; Maternal Exposure - statistics & numerical data ; New Hampshire - epidemiology ; Newborn infants ; Pregnancy ; Pregnancy Outcome - epidemiology ; Studies ; Water, Underground ; Womens health
  • É parte de: Environmental health perspectives, 2016-08, Vol.124 (8), p.1299-1307
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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    These authors contributed equally to this work.
  • Descrição: Studies suggest that arsenic exposure influences birth outcomes; however, findings are mixed. We assessed in utero arsenic exposure in relation to birth outcomes and whether maternal prepregnancy weight and infant sex modified the associations. Among 706 mother-infant pairs exposed to low levels of arsenic through drinking water and diet, we assessed in utero arsenic exposure using maternal second-trimester urinary arsenic, maternal prepregnancy weight through self-report, and birth outcomes from medical records. Median (interquartile range) of total urinary arsenic [tAs; inorganic arsenic (iAs) + monomethylarsonic acid (MMA) + dimethylarsinic acid (DMA)] was 3.4 μg/L (1.7-6.0). In adjusted linear models, each doubling of tAs was associated with a 0.10-cm decrease (95% CI: -0.19, -0.01) in head circumference. Results were similar for MMA and DMA. Ln(tAs) and ln(DMA) were positively associated with birth length in infant males only; among males, each doubling of tAs was associated with a 0.28-cm increase (95% CI: 0.09, 0.46) in birth length (pinteraction = 0.04). Results were similar for DMA. Additionally, arsenic exposure was inversely related to ponderal index, and associations differed by maternal weight. Each ln(tAs) doubling of tAs was associated with a 0.55-kg/m3 lower (95% CI: -0.82, -0.28, p < 0.001) ponderal index for infants of overweight/obese, but not normal-weight, mothers (pinteraction < 0.01). Finally, there was a significant interaction between maternal weight status, infant sex, and arsenic exposure on birth weight (pinteraction = 0.03). In girls born of overweight/obese mothers, each doubling of tAs was associated with a 62.9-g decrease (95% CI: -111.6, -14.2) in birth weight, though the association was null in the other strata. Low-level arsenic exposure may affect fetal growth, and the associations may be modified by maternal weight status and infant sex. Gilbert-Diamond D, Emond JA, Baker ER, Korrick SA, Karagas MR. 2016. Relation between in utero arsenic exposure and birth outcomes in a cohort of mothers and their newborns from New Hampshire. Environ Health Perspect 124:1299-1307; http://dx.doi.org/10.1289/ehp.1510065.
  • Editor: United States: National Institute of Environmental Health Sciences
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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