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Plasma Biomarkers of Myocardial Fibrosis and Remodeling in Terminal Heart Failure Patients Supported by Mechanical Circulatory Support Devices

Milting, Hendrik, MSc, PhD ; Ellinghaus, Peter, PhD ; Seewald, Michael, PhD ; Cakar, Hamdin, MSc ; Bohms, Birte, TC ; Kassner, Astrid, MSc ; Körfer, Reiner, MD, PhD ; Klein, Martina, VMD ; Krahn, Thomas, PhD ; Kruska, Lothar, PhD ; El Banayosy, Aly, MD ; Kramer, Frank, PhD

The Journal of heart and lung transplantation, 2008-06, Vol.27 (6), p.589-596 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Plasma Biomarkers of Myocardial Fibrosis and Remodeling in Terminal Heart Failure Patients Supported by Mechanical Circulatory Support Devices
Autor: Milting, Hendrik, MSc, PhD ; Ellinghaus, Peter, PhD ; Seewald, Michael, PhD ; Cakar, Hamdin, MSc ; Bohms, Birte, TC ; Kassner, Astrid, MSc ; Körfer, Reiner, MD, PhD ; Klein, Martina, VMD ; Krahn, Thomas, PhD ; Kruska, Lothar, PhD ; El Banayosy, Aly, MD ; Kramer, Frank, PhD
Assuntos: Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Case-Control Studies ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Endomyocardial Fibrosis - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Galectin 3 - blood ; Heart ; Heart Failure - blood ; Heart Failure - physiopathology ; Heart Failure - surgery ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart-Assist Devices ; Humans ; Intensive care medicine ; Male ; Matrix Metalloproteinase 1 - blood ; Matrix Metalloproteinase 2 - blood ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Osteopontin - blood ; Severity of Illness Index ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Tenascin - blood ; Ventricular Remodeling
É parte de: The Journal of heart and lung transplantation, 2008-06, Vol.27 (6), p.589-596
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Descrição: Background In this study we analyzed putative biomarkers for myocardial remodeling in plasma from 55 endstage heart failure patients with the need for mechanical circulatory support (MCS). We compared our data to 40 healthy controls and examined if MCS by either ventricular assist devices or total artificial hearts has an impact on plasma concentrations of remodeling biomarkers. Methods & Results Plasma biomarkers were analysed pre and 30 days post implantation of a MCS device using commercially available enzyme linked immunosorbent assays (ELISA). We observed that the plasma concentrations of remodeling biomarkers: tissue inhibitor of metalloproteinase 1 (TIMP1), tenascin C (TNC), galectin 3 (LGALS3), osteopontin (OPN) and of neurohumoral biomarker brain natriuretic peptide (BNP), are significantly elevated in patients with terminal heart failure compared to healthy controls. We did not find elevated plasma concentrations for matrix metalloproteinase 2 (MMP2) and procollagen I C-terminal peptide (PCIP). However, only BNP plasma levels were reduced by MCS, whereas the concentrations of remodeling biomarkers remained elevated or even increased further 30 days after MCS. LGALS3 plasma concentrations at device implantation were significantly higher in patients who did not survive MCS due to multi organ failure (MOF). Conclusions Our findings indicate that mechanical unloading in endstage heart failure is not reflected by a rapid reduction of remodeling plasma biomarkers.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Plasma Biomarkers of Myocardial Fibrosis and Remodeling in Terminal Heart Failure Patients Supported by Mechanical Circulatory Support Devices

Milting, Hendrik, MSc, PhD ; Ellinghaus, Peter, PhD ; Seewald, Michael, PhD ; Cakar, Hamdin, MSc ; Bohms, Birte, TC ; Kassner, Astrid, MSc ; Körfer, Reiner, MD, PhD ; Klein, Martina, VMD ; Krahn, Thomas, PhD ; Kruska, Lothar, PhD ; El Banayosy, Aly, MD ; Kramer, Frank, PhD

New York, NY: Elsevier Inc

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